Anti-WLS/ C1orf139/ EVI monoclonal antibody

Anti-WLS/ C1orf139/ EVI antibody for FACS & in-vivo assay

Target products collectionGo to WLS/WLS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1933-Ab-1/ GM-Tg-hg-MP1933-Ab-2Anti-Human WLS monoclonal antibodyHuman
GM-Tg-rg-MP1933-Ab-1/ GM-Tg-rg-MP1933-Ab-2Anti-Rat WLS monoclonal antibodyRat
GM-Tg-mg-MP1933-Ab-1/ GM-Tg-mg-MP1933-Ab-2Anti-Mouse WLS monoclonal antibodyMouse
GM-Tg-cynog-MP1933-Ab-1/ GM-Tg-cynog-MP1933-Ab-2Anti-Cynomolgus/ Rhesus macaque WLS monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1933-Ab-1/ GM-Tg-felg-MP1933-Ab-2Anti-Feline WLS monoclonal antibodyFeline
GM-Tg-cang-MP1933-Ab-1/ GM-Tg-cang-MP1933-Ab-2Anti-Canine WLS monoclonal antibodyCanine
GM-Tg-bovg-MP1933-Ab-1/ GM-Tg-bovg-MP1933-Ab-2Anti-Bovine WLS monoclonal antibodyBovine
GM-Tg-equg-MP1933-Ab-1/ GM-Tg-equg-MP1933-Ab-2Anti-Equine WLS monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1933-Ab-1/ GM-Tg-hg-MP1933-Ab-2; GM-Tg-rg-MP1933-Ab-1/ GM-Tg-rg-MP1933-Ab-2;
GM-Tg-mg-MP1933-Ab-1/ GM-Tg-mg-MP1933-Ab-2; GM-Tg-cynog-MP1933-Ab-1/ GM-Tg-cynog-MP1933-Ab-2;
GM-Tg-felg-MP1933-Ab-1/ GM-Tg-felg-MP1933-Ab-2; GM-Tg-cang-MP1933-Ab-1/ GM-Tg-cang-MP1933-Ab-2;
GM-Tg-bovg-MP1933-Ab-1/ GM-Tg-bovg-MP1933-Ab-2; GM-Tg-equg-MP1933-Ab-1/ GM-Tg-equg-MP1933-Ab-2
Products NameAnti-WLS monoclonal antibody
Formatmab
Target NameWLS
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-WLS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species WLS/ C1orf139/ EVI VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1933
    Target NameWLS
    Gene ID79971,68151,362065,701411,611491,101089632,528123,100053710
    Gene Symbol and Synonyms5031439A09Rik,C1orf139,EVI,GPR177,mig-14,MRP,WLS,ZKS
    Uniprot AccessionQ5T9L3,Q6P689
    Uniprot Entry NameWLS_HUMAN,WLS_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000116729
    Target ClassificationN/A

    The target: WLS, gene name: WLS, also named as C1orf139, EVI, GPR177, MRP, mig-14. Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.