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Anti-YBOX1/ YBX1/ BP-8 monoclonal antibody
Anti-YBOX1/ YBX1/ BP-8 antibody for FACS & in-vivo assay
Go to YBX1/YBX1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1951-Ab-1/ GM-Tg-hg-MP1951-Ab-2 | Anti-Human YBX1 monoclonal antibody | Human |
| GM-Tg-rg-MP1951-Ab-1/ GM-Tg-rg-MP1951-Ab-2 | Anti-Rat YBX1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1951-Ab-1/ GM-Tg-mg-MP1951-Ab-2 | Anti-Mouse YBX1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1951-Ab-1/ GM-Tg-cynog-MP1951-Ab-2 | Anti-Cynomolgus/ Rhesus macaque YBX1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1951-Ab-1/ GM-Tg-felg-MP1951-Ab-2 | Anti-Feline YBX1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1951-Ab-1/ GM-Tg-cang-MP1951-Ab-2 | Anti-Canine YBX1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1951-Ab-1/ GM-Tg-bovg-MP1951-Ab-2 | Anti-Bovine YBX1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1951-Ab-1/ GM-Tg-equg-MP1951-Ab-2 | Anti-Equine YBX1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1951-Ab-1/ GM-Tg-hg-MP1951-Ab-2; GM-Tg-rg-MP1951-Ab-1/ GM-Tg-rg-MP1951-Ab-2; GM-Tg-mg-MP1951-Ab-1/ GM-Tg-mg-MP1951-Ab-2; GM-Tg-cynog-MP1951-Ab-1/ GM-Tg-cynog-MP1951-Ab-2; GM-Tg-felg-MP1951-Ab-1/ GM-Tg-felg-MP1951-Ab-2; GM-Tg-cang-MP1951-Ab-1/ GM-Tg-cang-MP1951-Ab-2; GM-Tg-bovg-MP1951-Ab-1/ GM-Tg-bovg-MP1951-Ab-2; GM-Tg-equg-MP1951-Ab-1/ GM-Tg-equg-MP1951-Ab-2 |
| Products Name | Anti-YBX1 monoclonal antibody |
| Format | mab |
| Target Name | YBX1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-YBX1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species YBOX1/ YBX1/ BP-8 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000237 | human YBX1 Lentivirus particle |
| ORF Viral Vector | pGMLV000237 | human YBX1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000809 | house mouse Ybx1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000809 | house mouse Ybx1 Lentivirus particle |
Target information
| Target ID | GM-MP1951 |
| Target Name | YBX1 |
| Gene ID | 4904,22608,500538,700140,607025,102900263,287023,100067336 |
| Gene Symbol and Synonyms | 1700102N10Rik,BP-8,Byb1,CBF-A,Cbfa,CSDA2,CSDB,DBPB,EF1A,EFI-A,MDR-NF1,MSY1,mYB-1a,NSEP-1,NSEP1,YB-1,YB1,YBX1 |
| Uniprot Accession | P67809,P62961,P67808 |
| Uniprot Entry Name | YBOX1_HUMAN,YBOX1_RAT,YBOX1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000065978 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: YBX1, gene name: YBX1, also named as BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1. This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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