Anti-ZACN/ L2/ LGICZ monoclonal antibody

Anti-ZACN/ L2/ LGICZ antibody for FACS & in-vivo assay

Target products collectionGo to ZACN/ZACN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1955-Ab-1/ GM-Tg-hg-MP1955-Ab-2Anti-Human ZACN monoclonal antibodyHuman
GM-Tg-rg-MP1955-Ab-1/ GM-Tg-rg-MP1955-Ab-2Anti-Rat ZACN monoclonal antibodyRat
GM-Tg-mg-MP1955-Ab-1/ GM-Tg-mg-MP1955-Ab-2Anti-Mouse ZACN monoclonal antibodyMouse
GM-Tg-cynog-MP1955-Ab-1/ GM-Tg-cynog-MP1955-Ab-2Anti-Cynomolgus/ Rhesus macaque ZACN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1955-Ab-1/ GM-Tg-felg-MP1955-Ab-2Anti-Feline ZACN monoclonal antibodyFeline
GM-Tg-cang-MP1955-Ab-1/ GM-Tg-cang-MP1955-Ab-2Anti-Canine ZACN monoclonal antibodyCanine
GM-Tg-bovg-MP1955-Ab-1/ GM-Tg-bovg-MP1955-Ab-2Anti-Bovine ZACN monoclonal antibodyBovine
GM-Tg-equg-MP1955-Ab-1/ GM-Tg-equg-MP1955-Ab-2Anti-Equine ZACN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1955-Ab-1/ GM-Tg-hg-MP1955-Ab-2; GM-Tg-rg-MP1955-Ab-1/ GM-Tg-rg-MP1955-Ab-2;
GM-Tg-mg-MP1955-Ab-1/ GM-Tg-mg-MP1955-Ab-2; GM-Tg-cynog-MP1955-Ab-1/ GM-Tg-cynog-MP1955-Ab-2;
GM-Tg-felg-MP1955-Ab-1/ GM-Tg-felg-MP1955-Ab-2; GM-Tg-cang-MP1955-Ab-1/ GM-Tg-cang-MP1955-Ab-2;
GM-Tg-bovg-MP1955-Ab-1/ GM-Tg-bovg-MP1955-Ab-2; GM-Tg-equg-MP1955-Ab-1/ GM-Tg-equg-MP1955-Ab-2
Products NameAnti-ZACN monoclonal antibody
Formatmab
Target NameZACN
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ZACN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ZACN/ L2/ LGICZ VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1955
    Target NameZACN
    Gene ID353174,705940,483326,101096685,789168,100630768
    Gene Symbol and SynonymsL2,LGICZ,LGICZ1,ZAC,ZAC1,ZACN
    Uniprot AccessionQ401N2,Q866Y9
    Uniprot Entry NameZACN_HUMAN,ZACN_CANLF
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000186919
    Target ClassificationN/A

    The target: ZACN, gene name: ZACN, also named as L2, LGICZ, LGICZ1, ZAC, ZAC1. LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.