Anti-AHNK/ AHNAK/ AHNAKRS monoclonal antibody

Anti-AHNK/ AHNAK/ AHNAKRS antibody for FACS & in-vivo assay

Target products collectionGo to AHNAK/AHNAK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1978-Ab-1/ GM-Tg-hg-MP1978-Ab-2Anti-Human AHNAK monoclonal antibodyHuman
GM-Tg-rg-MP1978-Ab-1/ GM-Tg-rg-MP1978-Ab-2Anti-Rat AHNAK monoclonal antibodyRat
GM-Tg-mg-MP1978-Ab-1/ GM-Tg-mg-MP1978-Ab-2Anti-Mouse AHNAK monoclonal antibodyMouse
GM-Tg-cynog-MP1978-Ab-1/ GM-Tg-cynog-MP1978-Ab-2Anti-Cynomolgus/ Rhesus macaque AHNAK monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1978-Ab-1/ GM-Tg-felg-MP1978-Ab-2Anti-Feline AHNAK monoclonal antibodyFeline
GM-Tg-cang-MP1978-Ab-1/ GM-Tg-cang-MP1978-Ab-2Anti-Canine AHNAK monoclonal antibodyCanine
GM-Tg-bovg-MP1978-Ab-1/ GM-Tg-bovg-MP1978-Ab-2Anti-Bovine AHNAK monoclonal antibodyBovine
GM-Tg-equg-MP1978-Ab-1/ GM-Tg-equg-MP1978-Ab-2Anti-Equine AHNAK monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1978-Ab-1/ GM-Tg-hg-MP1978-Ab-2; GM-Tg-rg-MP1978-Ab-1/ GM-Tg-rg-MP1978-Ab-2;
GM-Tg-mg-MP1978-Ab-1/ GM-Tg-mg-MP1978-Ab-2; GM-Tg-cynog-MP1978-Ab-1/ GM-Tg-cynog-MP1978-Ab-2;
GM-Tg-felg-MP1978-Ab-1/ GM-Tg-felg-MP1978-Ab-2; GM-Tg-cang-MP1978-Ab-1/ GM-Tg-cang-MP1978-Ab-2;
GM-Tg-bovg-MP1978-Ab-1/ GM-Tg-bovg-MP1978-Ab-2; GM-Tg-equg-MP1978-Ab-1/ GM-Tg-equg-MP1978-Ab-2
Products NameAnti-AHNAK monoclonal antibody
Formatmab
Target NameAHNAK
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AHNAK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species AHNK/ AHNAK/ AHNAKRS VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1978
    Target NameAHNAK
    Gene ID79026,66395,191572,718802,476059,101087783,531336,100063459
    Gene Symbol and SynonymsAHNAK,AHNAK 1,AHNAK1,AHNAKRS,DY6,PM227,RGD1308572,UV118
    Uniprot AccessionQ09666
    Uniprot Entry NameAHNK_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000124942
    Target ClassificationN/A

    The target: AHNAK, gene name: AHNAK, also named as AHNAKRS, PM227. The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. [provided by RefSeq, Oct 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.