Anti-AHNK2/ AHNAK2/ C14orf78 monoclonal antibody

Anti-AHNK2/ AHNAK2/ C14orf78 antibody for FACS & in-vivo assay

Target products collectionGo to AHNAK2/AHNAK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1979-Ab-1/ GM-Tg-hg-MP1979-Ab-2Anti-Human AHNAK2 monoclonal antibodyHuman
GM-Tg-rg-MP1979-Ab-1/ GM-Tg-rg-MP1979-Ab-2Anti-Rat AHNAK2 monoclonal antibodyRat
GM-Tg-mg-MP1979-Ab-1/ GM-Tg-mg-MP1979-Ab-2Anti-Mouse AHNAK2 monoclonal antibodyMouse
GM-Tg-cynog-MP1979-Ab-1/ GM-Tg-cynog-MP1979-Ab-2Anti-Cynomolgus/ Rhesus macaque AHNAK2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1979-Ab-1/ GM-Tg-felg-MP1979-Ab-2Anti-Feline AHNAK2 monoclonal antibodyFeline
GM-Tg-cang-MP1979-Ab-1/ GM-Tg-cang-MP1979-Ab-2Anti-Canine AHNAK2 monoclonal antibodyCanine
GM-Tg-bovg-MP1979-Ab-1/ GM-Tg-bovg-MP1979-Ab-2Anti-Bovine AHNAK2 monoclonal antibodyBovine
GM-Tg-equg-MP1979-Ab-1/ GM-Tg-equg-MP1979-Ab-2Anti-Equine AHNAK2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1979-Ab-1/ GM-Tg-hg-MP1979-Ab-2; GM-Tg-rg-MP1979-Ab-1/ GM-Tg-rg-MP1979-Ab-2;
GM-Tg-mg-MP1979-Ab-1/ GM-Tg-mg-MP1979-Ab-2; GM-Tg-cynog-MP1979-Ab-1/ GM-Tg-cynog-MP1979-Ab-2;
GM-Tg-felg-MP1979-Ab-1/ GM-Tg-felg-MP1979-Ab-2; GM-Tg-cang-MP1979-Ab-1/ GM-Tg-cang-MP1979-Ab-2;
GM-Tg-bovg-MP1979-Ab-1/ GM-Tg-bovg-MP1979-Ab-2; GM-Tg-equg-MP1979-Ab-1/ GM-Tg-equg-MP1979-Ab-2
Products NameAnti-AHNAK2 monoclonal antibody
Formatmab
Target NameAHNAK2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AHNAK2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species AHNK2/ AHNAK2/ C14orf78 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1979
    Target NameAHNAK2
    Gene ID113146,100041194,314478,707626,612700,105259630,527701,100146176
    Gene Symbol and SynonymsAHNAK2,C14orf78,Gm1185,Gm72,RGD1309696
    Uniprot AccessionQ8IVF2
    Uniprot Entry NameAHNK2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseProstate Cancer
    Gene EnsemblENSG00000185567
    Target ClassificationN/A

    The target: AHNAK2, gene name: AHNAK2, also named as C14orf78. This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.