Anti-AKA10/ AKAP10/ AKAP-10 monoclonal antibody

Anti-AKA10/ AKAP10/ AKAP-10 antibody for FACS & in-vivo assay

Target products collectionGo to AKAP10/AKAP10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1980-Ab-1/ GM-Tg-hg-MP1980-Ab-2Anti-Human AKAP10 monoclonal antibodyHuman
GM-Tg-rg-MP1980-Ab-1/ GM-Tg-rg-MP1980-Ab-2Anti-Rat AKAP10 monoclonal antibodyRat
GM-Tg-mg-MP1980-Ab-1/ GM-Tg-mg-MP1980-Ab-2Anti-Mouse AKAP10 monoclonal antibodyMouse
GM-Tg-cynog-MP1980-Ab-1/ GM-Tg-cynog-MP1980-Ab-2Anti-Cynomolgus/ Rhesus macaque AKAP10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1980-Ab-1/ GM-Tg-felg-MP1980-Ab-2Anti-Feline AKAP10 monoclonal antibodyFeline
GM-Tg-cang-MP1980-Ab-1/ GM-Tg-cang-MP1980-Ab-2Anti-Canine AKAP10 monoclonal antibodyCanine
GM-Tg-bovg-MP1980-Ab-1/ GM-Tg-bovg-MP1980-Ab-2Anti-Bovine AKAP10 monoclonal antibodyBovine
GM-Tg-equg-MP1980-Ab-1/ GM-Tg-equg-MP1980-Ab-2Anti-Equine AKAP10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1980-Ab-1/ GM-Tg-hg-MP1980-Ab-2; GM-Tg-rg-MP1980-Ab-1/ GM-Tg-rg-MP1980-Ab-2;
GM-Tg-mg-MP1980-Ab-1/ GM-Tg-mg-MP1980-Ab-2; GM-Tg-cynog-MP1980-Ab-1/ GM-Tg-cynog-MP1980-Ab-2;
GM-Tg-felg-MP1980-Ab-1/ GM-Tg-felg-MP1980-Ab-2; GM-Tg-cang-MP1980-Ab-1/ GM-Tg-cang-MP1980-Ab-2;
GM-Tg-bovg-MP1980-Ab-1/ GM-Tg-bovg-MP1980-Ab-2; GM-Tg-equg-MP1980-Ab-1/ GM-Tg-equg-MP1980-Ab-2
Products NameAnti-AKAP10 monoclonal antibody
Formatmab
Target NameAKAP10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AKAP10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species AKA10/ AKAP10/ AKAP-10 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1980
    Target NameAKAP10
    Gene ID11216,56697,360540,710970,609073,101096118,513802,100073152
    Gene Symbol and Synonyms1500031L16Rik,AKAP-10,AKAP10,B130049N18Rik,D-AKAP-2,D-AKAP2,PRKA10
    Uniprot AccessionO43572
    Uniprot Entry NameAKA10_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000108599
    Target ClassificationN/A

    The target: AKAP10, gene name: AKAP10, also named as AKAP-10, D-AKAP-2, D-AKAP2, PRKA10. This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.