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Anti-AKA12/ AKAP12/ AKAP250 monoclonal antibody
Anti-AKA12/ AKAP12/ AKAP250 antibody for FACS & in-vivo assay
Go to AKAP12/AKAP12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1981-Ab-1/ GM-Tg-hg-MP1981-Ab-2 | Anti-Human AKAP12 monoclonal antibody | Human |
| GM-Tg-rg-MP1981-Ab-1/ GM-Tg-rg-MP1981-Ab-2 | Anti-Rat AKAP12 monoclonal antibody | Rat |
| GM-Tg-mg-MP1981-Ab-1/ GM-Tg-mg-MP1981-Ab-2 | Anti-Mouse AKAP12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1981-Ab-1/ GM-Tg-cynog-MP1981-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AKAP12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1981-Ab-1/ GM-Tg-felg-MP1981-Ab-2 | Anti-Feline AKAP12 monoclonal antibody | Feline |
| GM-Tg-cang-MP1981-Ab-1/ GM-Tg-cang-MP1981-Ab-2 | Anti-Canine AKAP12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1981-Ab-1/ GM-Tg-bovg-MP1981-Ab-2 | Anti-Bovine AKAP12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1981-Ab-1/ GM-Tg-equg-MP1981-Ab-2 | Anti-Equine AKAP12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1981-Ab-1/ GM-Tg-hg-MP1981-Ab-2; GM-Tg-rg-MP1981-Ab-1/ GM-Tg-rg-MP1981-Ab-2; GM-Tg-mg-MP1981-Ab-1/ GM-Tg-mg-MP1981-Ab-2; GM-Tg-cynog-MP1981-Ab-1/ GM-Tg-cynog-MP1981-Ab-2; GM-Tg-felg-MP1981-Ab-1/ GM-Tg-felg-MP1981-Ab-2; GM-Tg-cang-MP1981-Ab-1/ GM-Tg-cang-MP1981-Ab-2; GM-Tg-bovg-MP1981-Ab-1/ GM-Tg-bovg-MP1981-Ab-2; GM-Tg-equg-MP1981-Ab-1/ GM-Tg-equg-MP1981-Ab-2 |
| Products Name | Anti-AKAP12 monoclonal antibody |
| Format | mab |
| Target Name | AKAP12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AKAP12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AKA12/ AKAP12/ AKAP250 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1981 |
| Target Name | AKAP12 |
| Gene ID | 9590,83397,83425,641446,476246,101083007,513774,100063263 |
| Gene Symbol and Synonyms | AKAP12,AKAP12A,AKAP12B,AKAP12G,AKAP250,Srcs5,SSeCKS,Tsga12 |
| Uniprot Accession | Q02952,Q5QD51 |
| Uniprot Entry Name | AKA12_HUMAN,AKA12_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Esophagus Cancer |
| Gene Ensembl | ENSG00000131016 |
| Target Classification | N/A |
The target: AKAP12, gene name: AKAP12, also named as AKAP250, SSeCKS. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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