Anti-AMER1/ FAM123B/ OSCS monoclonal antibody

Anti-AMER1/ FAM123B/ OSCS antibody for FACS & in-vivo assay

Target products collectionGo to AMER1/AMER1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1984-Ab-1/ GM-Tg-hg-MP1984-Ab-2Anti-Human AMER1 monoclonal antibodyHuman
GM-Tg-rg-MP1984-Ab-1/ GM-Tg-rg-MP1984-Ab-2Anti-Rat AMER1 monoclonal antibodyRat
GM-Tg-mg-MP1984-Ab-1/ GM-Tg-mg-MP1984-Ab-2Anti-Mouse AMER1 monoclonal antibodyMouse
GM-Tg-cynog-MP1984-Ab-1/ GM-Tg-cynog-MP1984-Ab-2Anti-Cynomolgus/ Rhesus macaque AMER1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1984-Ab-1/ GM-Tg-felg-MP1984-Ab-2Anti-Feline AMER1 monoclonal antibodyFeline
GM-Tg-cang-MP1984-Ab-1/ GM-Tg-cang-MP1984-Ab-2Anti-Canine AMER1 monoclonal antibodyCanine
GM-Tg-bovg-MP1984-Ab-1/ GM-Tg-bovg-MP1984-Ab-2Anti-Bovine AMER1 monoclonal antibodyBovine
GM-Tg-equg-MP1984-Ab-1/ GM-Tg-equg-MP1984-Ab-2Anti-Equine AMER1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1984-Ab-1/ GM-Tg-hg-MP1984-Ab-2; GM-Tg-rg-MP1984-Ab-1/ GM-Tg-rg-MP1984-Ab-2;
GM-Tg-mg-MP1984-Ab-1/ GM-Tg-mg-MP1984-Ab-2; GM-Tg-cynog-MP1984-Ab-1/ GM-Tg-cynog-MP1984-Ab-2;
GM-Tg-felg-MP1984-Ab-1/ GM-Tg-felg-MP1984-Ab-2; GM-Tg-cang-MP1984-Ab-1/ GM-Tg-cang-MP1984-Ab-2;
GM-Tg-bovg-MP1984-Ab-1/ GM-Tg-bovg-MP1984-Ab-2; GM-Tg-equg-MP1984-Ab-1/ GM-Tg-equg-MP1984-Ab-2
Products NameAnti-AMER1 monoclonal antibody
Formatmab
Target NameAMER1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AMER1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species AMER1/ FAM123B/ OSCS VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1984
    Target NameAMER1
    Gene ID139285,72345,501584,707700,606822,101099359,539029,100054310
    Gene Symbol and Synonyms2810002O09Rik,AMER1,FAM123B,OSCS,RGD1560322,WTX
    Uniprot AccessionQ5JTC6
    Uniprot Entry NameAMER1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000184675
    Target ClassificationTumor-associated antigen (TAA)

    The target: AMER1, gene name: AMER1, also named as FAM123B, OSCS, WTX. The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.