Anti-AMOL2/ AMOTL2/ LCCP monoclonal antibody

Anti-AMOL2/ AMOTL2/ LCCP antibody for FACS & in-vivo assay

Target products collectionGo to AMOTL2/AMOTL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1986-Ab-1/ GM-Tg-hg-MP1986-Ab-2Anti-Human AMOTL2 monoclonal antibodyHuman
GM-Tg-rg-MP1986-Ab-1/ GM-Tg-rg-MP1986-Ab-2Anti-Rat AMOTL2 monoclonal antibodyRat
GM-Tg-mg-MP1986-Ab-1/ GM-Tg-mg-MP1986-Ab-2Anti-Mouse AMOTL2 monoclonal antibodyMouse
GM-Tg-cynog-MP1986-Ab-1/ GM-Tg-cynog-MP1986-Ab-2Anti-Cynomolgus/ Rhesus macaque AMOTL2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1986-Ab-1/ GM-Tg-felg-MP1986-Ab-2Anti-Feline AMOTL2 monoclonal antibodyFeline
GM-Tg-cang-MP1986-Ab-1/ GM-Tg-cang-MP1986-Ab-2Anti-Canine AMOTL2 monoclonal antibodyCanine
GM-Tg-bovg-MP1986-Ab-1/ GM-Tg-bovg-MP1986-Ab-2Anti-Bovine AMOTL2 monoclonal antibodyBovine
GM-Tg-equg-MP1986-Ab-1/ GM-Tg-equg-MP1986-Ab-2Anti-Equine AMOTL2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1986-Ab-1/ GM-Tg-hg-MP1986-Ab-2; GM-Tg-rg-MP1986-Ab-1/ GM-Tg-rg-MP1986-Ab-2;
GM-Tg-mg-MP1986-Ab-1/ GM-Tg-mg-MP1986-Ab-2; GM-Tg-cynog-MP1986-Ab-1/ GM-Tg-cynog-MP1986-Ab-2;
GM-Tg-felg-MP1986-Ab-1/ GM-Tg-felg-MP1986-Ab-2; GM-Tg-cang-MP1986-Ab-1/ GM-Tg-cang-MP1986-Ab-2;
GM-Tg-bovg-MP1986-Ab-1/ GM-Tg-bovg-MP1986-Ab-2; GM-Tg-equg-MP1986-Ab-1/ GM-Tg-equg-MP1986-Ab-2
Products NameAnti-AMOTL2 monoclonal antibody
Formatmab
Target NameAMOTL2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AMOTL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species AMOL2/ AMOTL2/ LCCP VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1986
    Target NameAMOTL2
    Gene ID51421,56332,65157,485669,101086593,538514,100053062
    Gene Symbol and SynonymsAMOTL2,LCCP,MASCOT,mKIAA0989
    Uniprot AccessionQ9Y2J4,G3V735,F1MRK3
    Uniprot Entry NameAMOL2_HUMAN,AMOL2_RAT,AMOL2_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000114019
    Target ClassificationN/A

    The target: AMOTL2, gene name: AMOTL2, also named as LCCP. Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.