- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-ANK2/ ANK-2/ LQT4 monoclonal antibody
Anti-ANK2/ ANK-2/ LQT4 antibody for FACS & in-vivo assay
Go to ANK2/ANK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1988-Ab-1/ GM-Tg-hg-MP1988-Ab-2 | Anti-Human ANK2 monoclonal antibody | Human |
| GM-Tg-rg-MP1988-Ab-1/ GM-Tg-rg-MP1988-Ab-2 | Anti-Rat ANK2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1988-Ab-1/ GM-Tg-mg-MP1988-Ab-2 | Anti-Mouse ANK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1988-Ab-1/ GM-Tg-cynog-MP1988-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ANK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1988-Ab-1/ GM-Tg-felg-MP1988-Ab-2 | Anti-Feline ANK2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1988-Ab-1/ GM-Tg-cang-MP1988-Ab-2 | Anti-Canine ANK2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1988-Ab-1/ GM-Tg-bovg-MP1988-Ab-2 | Anti-Bovine ANK2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1988-Ab-1/ GM-Tg-equg-MP1988-Ab-2 | Anti-Equine ANK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1988-Ab-1/ GM-Tg-hg-MP1988-Ab-2; GM-Tg-rg-MP1988-Ab-1/ GM-Tg-rg-MP1988-Ab-2; GM-Tg-mg-MP1988-Ab-1/ GM-Tg-mg-MP1988-Ab-2; GM-Tg-cynog-MP1988-Ab-1/ GM-Tg-cynog-MP1988-Ab-2; GM-Tg-felg-MP1988-Ab-1/ GM-Tg-felg-MP1988-Ab-2; GM-Tg-cang-MP1988-Ab-1/ GM-Tg-cang-MP1988-Ab-2; GM-Tg-bovg-MP1988-Ab-1/ GM-Tg-bovg-MP1988-Ab-2; GM-Tg-equg-MP1988-Ab-1/ GM-Tg-equg-MP1988-Ab-2 |
| Products Name | Anti-ANK2 monoclonal antibody |
| Format | mab |
| Target Name | ANK2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ANK2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ANK2/ ANK-2/ LQT4 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1988 |
| Target Name | ANK2 |
| Gene ID | 287,109676,362036,702180,487908,101100129,539238,100064198 |
| Gene Symbol and Synonyms | 100043364,ANK-2,ANK2,Ank3,ANKB,brank-2,CFAP87,FAP87,Gm4392,LQT4 |
| Uniprot Accession | Q01484 |
| Uniprot Entry Name | ANK2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000145362 |
| Target Classification | N/A |
The target: ANK2, gene name: ANK2, also named as ANK-2, LQT4, brank-2. This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
