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Anti-AP2M1/ AP50/ CLAPM1 monoclonal antibody
Anti-AP2M1/ AP50/ CLAPM1 antibody for FACS & in-vivo assay
Go to AP2M1/AP2M1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1993-Ab-1/ GM-Tg-hg-MP1993-Ab-2 | Anti-Human AP2M1 monoclonal antibody | Human |
| GM-Tg-rg-MP1993-Ab-1/ GM-Tg-rg-MP1993-Ab-2 | Anti-Rat AP2M1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1993-Ab-1/ GM-Tg-mg-MP1993-Ab-2 | Anti-Mouse AP2M1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1993-Ab-1/ GM-Tg-cynog-MP1993-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AP2M1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1993-Ab-1/ GM-Tg-felg-MP1993-Ab-2 | Anti-Feline AP2M1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1993-Ab-1/ GM-Tg-cang-MP1993-Ab-2 | Anti-Canine AP2M1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1993-Ab-1/ GM-Tg-bovg-MP1993-Ab-2 | Anti-Bovine AP2M1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1993-Ab-1/ GM-Tg-equg-MP1993-Ab-2 | Anti-Equine AP2M1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1993-Ab-1/ GM-Tg-hg-MP1993-Ab-2; GM-Tg-rg-MP1993-Ab-1/ GM-Tg-rg-MP1993-Ab-2; GM-Tg-mg-MP1993-Ab-1/ GM-Tg-mg-MP1993-Ab-2; GM-Tg-cynog-MP1993-Ab-1/ GM-Tg-cynog-MP1993-Ab-2; GM-Tg-felg-MP1993-Ab-1/ GM-Tg-felg-MP1993-Ab-2; GM-Tg-cang-MP1993-Ab-1/ GM-Tg-cang-MP1993-Ab-2; GM-Tg-bovg-MP1993-Ab-1/ GM-Tg-bovg-MP1993-Ab-2; GM-Tg-equg-MP1993-Ab-1/ GM-Tg-equg-MP1993-Ab-2 |
| Products Name | Anti-AP2M1 monoclonal antibody |
| Format | mab |
| Target Name | AP2M1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AP2M1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AP2M1/ AP50/ CLAPM1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000610 | human AP2M1 Lentivirus particle |
| ORF Viral Vector | pGMLP000610 | human AP2M1 Lentivirus plasmid |
Target information
| Target ID | GM-MP1993 |
| Target Name | AP2M1 |
| Gene ID | 1173,11773,116563,703554,607139,101088686,517446,100058961 |
| Gene Symbol and Synonyms | AP2M1,AP50,CLAPM1,MRD60,mu2 |
| Uniprot Accession | Q96CW1,P84092,Q3ZC13 |
| Uniprot Entry Name | AP2M1_HUMAN,AP2M1_RAT,AP2M1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000161203 |
| Target Classification | N/A |
The target: AP2M1, gene name: AP2M1, also named as AP50, CLAPM1, mu2. This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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