Anti-RHG21/ ARHGAP21/ ARHGAP10 monoclonal antibody

Anti-RHG21/ ARHGAP21/ ARHGAP10 antibody for FACS & in-vivo assay

Target products collectionGo to ARHGAP21/ARHGAP21 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1998-Ab-1/ GM-Tg-hg-MP1998-Ab-2Anti-Human ARHGAP21 monoclonal antibodyHuman
GM-Tg-rg-MP1998-Ab-1/ GM-Tg-rg-MP1998-Ab-2Anti-Rat ARHGAP21 monoclonal antibodyRat
GM-Tg-mg-MP1998-Ab-1/ GM-Tg-mg-MP1998-Ab-2Anti-Mouse ARHGAP21 monoclonal antibodyMouse
GM-Tg-cynog-MP1998-Ab-1/ GM-Tg-cynog-MP1998-Ab-2Anti-Cynomolgus/ Rhesus macaque ARHGAP21 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1998-Ab-1/ GM-Tg-felg-MP1998-Ab-2Anti-Feline ARHGAP21 monoclonal antibodyFeline
GM-Tg-cang-MP1998-Ab-1/ GM-Tg-cang-MP1998-Ab-2Anti-Canine ARHGAP21 monoclonal antibodyCanine
GM-Tg-bovg-MP1998-Ab-1/ GM-Tg-bovg-MP1998-Ab-2Anti-Bovine ARHGAP21 monoclonal antibodyBovine
GM-Tg-equg-MP1998-Ab-1/ GM-Tg-equg-MP1998-Ab-2Anti-Equine ARHGAP21 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1998-Ab-1/ GM-Tg-hg-MP1998-Ab-2; GM-Tg-rg-MP1998-Ab-1/ GM-Tg-rg-MP1998-Ab-2;
GM-Tg-mg-MP1998-Ab-1/ GM-Tg-mg-MP1998-Ab-2; GM-Tg-cynog-MP1998-Ab-1/ GM-Tg-cynog-MP1998-Ab-2;
GM-Tg-felg-MP1998-Ab-1/ GM-Tg-felg-MP1998-Ab-2; GM-Tg-cang-MP1998-Ab-1/ GM-Tg-cang-MP1998-Ab-2;
GM-Tg-bovg-MP1998-Ab-1/ GM-Tg-bovg-MP1998-Ab-2; GM-Tg-equg-MP1998-Ab-1/ GM-Tg-equg-MP1998-Ab-2
Products NameAnti-ARHGAP21 monoclonal antibody
Formatmab
Target NameARHGAP21
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ARHGAP21 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species RHG21/ ARHGAP21/ ARHGAP10 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1998
    Target NameARHGAP21
    Gene ID57584,71435,307178,706428,100687590,101086237,538584,100066007
    Gene Symbol and Synonyms5530401C11Rik,ARHGAP10,ARHGAP21
    Uniprot AccessionQ5T5U3
    Uniprot Entry NameRHG21_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000107863
    Target ClassificationN/A

    The target: ARHGAP21, gene name: ARHGAP21, also named as ARHGAP10. ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.