Anti-ARHGB/ ARHGEF11/ GTRAP48 monoclonal antibody

Anti-ARHGB/ ARHGEF11/ GTRAP48 antibody for FACS & in-vivo assay

Target products collectionGo to ARHGEF11/ARHGEF11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2002-Ab-1/ GM-Tg-hg-MP2002-Ab-2Anti-Human ARHGEF11 monoclonal antibodyHuman
GM-Tg-rg-MP2002-Ab-1/ GM-Tg-rg-MP2002-Ab-2Anti-Rat ARHGEF11 monoclonal antibodyRat
GM-Tg-mg-MP2002-Ab-1/ GM-Tg-mg-MP2002-Ab-2Anti-Mouse ARHGEF11 monoclonal antibodyMouse
GM-Tg-cynog-MP2002-Ab-1/ GM-Tg-cynog-MP2002-Ab-2Anti-Cynomolgus/ Rhesus macaque ARHGEF11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2002-Ab-1/ GM-Tg-felg-MP2002-Ab-2Anti-Feline ARHGEF11 monoclonal antibodyFeline
GM-Tg-cang-MP2002-Ab-1/ GM-Tg-cang-MP2002-Ab-2Anti-Canine ARHGEF11 monoclonal antibodyCanine
GM-Tg-bovg-MP2002-Ab-1/ GM-Tg-bovg-MP2002-Ab-2Anti-Bovine ARHGEF11 monoclonal antibodyBovine
GM-Tg-equg-MP2002-Ab-1/ GM-Tg-equg-MP2002-Ab-2Anti-Equine ARHGEF11 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2002-Ab-1/ GM-Tg-hg-MP2002-Ab-2; GM-Tg-rg-MP2002-Ab-1/ GM-Tg-rg-MP2002-Ab-2;
GM-Tg-mg-MP2002-Ab-1/ GM-Tg-mg-MP2002-Ab-2; GM-Tg-cynog-MP2002-Ab-1/ GM-Tg-cynog-MP2002-Ab-2;
GM-Tg-felg-MP2002-Ab-1/ GM-Tg-felg-MP2002-Ab-2; GM-Tg-cang-MP2002-Ab-1/ GM-Tg-cang-MP2002-Ab-2;
GM-Tg-bovg-MP2002-Ab-1/ GM-Tg-bovg-MP2002-Ab-2; GM-Tg-equg-MP2002-Ab-1/ GM-Tg-equg-MP2002-Ab-2
Products NameAnti-ARHGEF11 monoclonal antibody
Formatmab
Target NameARHGEF11
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ARHGEF11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ARHGB/ ARHGEF11/ GTRAP48 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2002
    Target NameARHGEF11
    Gene ID9826,213498,78966,718727,490402,101080861,511220,100064689
    Gene Symbol and SynonymsARHGEF11,GTRAP48,mKIAA0380,PDZ-RHOGEF,Prg,RhoGEF
    Uniprot AccessionO15085,Q9ES67
    Uniprot Entry NameARHGB_HUMAN,ARHGB_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000132694
    Target ClassificationN/A

    The target: ARHGEF11, gene name: ARHGEF11, also named as GTRAP48, PDZ-RHOGEF. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.