Anti-ARG28/ ARHGEF28/ RGNEF monoclonal antibody

Anti-ARG28/ ARHGEF28/ RGNEF antibody for FACS & in-vivo assay

Target products collectionGo to ARHGEF28/ARHGEF28 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2003-Ab-1/ GM-Tg-hg-MP2003-Ab-2Anti-Human ARHGEF28 monoclonal antibodyHuman
GM-Tg-rg-MP2003-Ab-1/ GM-Tg-rg-MP2003-Ab-2Anti-Rat ARHGEF28 monoclonal antibodyRat
GM-Tg-mg-MP2003-Ab-1/ GM-Tg-mg-MP2003-Ab-2Anti-Mouse ARHGEF28 monoclonal antibodyMouse
GM-Tg-cynog-MP2003-Ab-1/ GM-Tg-cynog-MP2003-Ab-2Anti-Cynomolgus/ Rhesus macaque ARHGEF28 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2003-Ab-1/ GM-Tg-felg-MP2003-Ab-2Anti-Feline ARHGEF28 monoclonal antibodyFeline
GM-Tg-cang-MP2003-Ab-1/ GM-Tg-cang-MP2003-Ab-2Anti-Canine ARHGEF28 monoclonal antibodyCanine
GM-Tg-bovg-MP2003-Ab-1/ GM-Tg-bovg-MP2003-Ab-2Anti-Bovine ARHGEF28 monoclonal antibodyBovine
GM-Tg-equg-MP2003-Ab-1/ GM-Tg-equg-MP2003-Ab-2Anti-Equine ARHGEF28 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2003-Ab-1/ GM-Tg-hg-MP2003-Ab-2; GM-Tg-rg-MP2003-Ab-1/ GM-Tg-rg-MP2003-Ab-2;
GM-Tg-mg-MP2003-Ab-1/ GM-Tg-mg-MP2003-Ab-2; GM-Tg-cynog-MP2003-Ab-1/ GM-Tg-cynog-MP2003-Ab-2;
GM-Tg-felg-MP2003-Ab-1/ GM-Tg-felg-MP2003-Ab-2; GM-Tg-cang-MP2003-Ab-1/ GM-Tg-cang-MP2003-Ab-2;
GM-Tg-bovg-MP2003-Ab-1/ GM-Tg-bovg-MP2003-Ab-2; GM-Tg-equg-MP2003-Ab-1/ GM-Tg-equg-MP2003-Ab-2
Products NameAnti-ARHGEF28 monoclonal antibody
Formatmab
Target NameARHGEF28
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ARHGEF28 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ARG28/ ARHGEF28/ RGNEF VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2003
    Target NameARHGEF28
    Gene ID64283,110596,361882,703897,487245,101094325,616969,100073291
    Gene Symbol and Synonyms9230110L08Rik,ARHGEF28,D13Bwg1089e,p190RHOGEF,RGNEF,RhoGEF,Rhoip2,RIP2
    Uniprot AccessionQ8N1W1,P0C6P5
    Uniprot Entry NameARG28_HUMAN,ARG28_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000214944
    Target ClassificationN/A

    The target: ARHGEF28, gene name: ARHGEF28, also named as RGNEF, RIP2, p190RHOGEF. This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.