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Anti-ARI4A/ ARID4A/ RBBP-1 monoclonal antibody
Anti-ARI4A/ ARID4A/ RBBP-1 antibody for FACS & in-vivo assay
Go to ARID4A/ARID4A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2006-Ab-1/ GM-Tg-hg-MP2006-Ab-2 | Anti-Human ARID4A monoclonal antibody | Human |
| GM-Tg-rg-MP2006-Ab-1/ GM-Tg-rg-MP2006-Ab-2 | Anti-Rat ARID4A monoclonal antibody | Rat |
| GM-Tg-mg-MP2006-Ab-1/ GM-Tg-mg-MP2006-Ab-2 | Anti-Mouse ARID4A monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2006-Ab-1/ GM-Tg-cynog-MP2006-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ARID4A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2006-Ab-1/ GM-Tg-felg-MP2006-Ab-2 | Anti-Feline ARID4A monoclonal antibody | Feline |
| GM-Tg-cang-MP2006-Ab-1/ GM-Tg-cang-MP2006-Ab-2 | Anti-Canine ARID4A monoclonal antibody | Canine |
| GM-Tg-bovg-MP2006-Ab-1/ GM-Tg-bovg-MP2006-Ab-2 | Anti-Bovine ARID4A monoclonal antibody | Bovine |
| GM-Tg-equg-MP2006-Ab-1/ GM-Tg-equg-MP2006-Ab-2 | Anti-Equine ARID4A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2006-Ab-1/ GM-Tg-hg-MP2006-Ab-2; GM-Tg-rg-MP2006-Ab-1/ GM-Tg-rg-MP2006-Ab-2; GM-Tg-mg-MP2006-Ab-1/ GM-Tg-mg-MP2006-Ab-2; GM-Tg-cynog-MP2006-Ab-1/ GM-Tg-cynog-MP2006-Ab-2; GM-Tg-felg-MP2006-Ab-1/ GM-Tg-felg-MP2006-Ab-2; GM-Tg-cang-MP2006-Ab-1/ GM-Tg-cang-MP2006-Ab-2; GM-Tg-bovg-MP2006-Ab-1/ GM-Tg-bovg-MP2006-Ab-2; GM-Tg-equg-MP2006-Ab-1/ GM-Tg-equg-MP2006-Ab-2 |
| Products Name | Anti-ARID4A monoclonal antibody |
| Format | mab |
| Target Name | ARID4A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ARID4A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ARI4A/ ARID4A/ RBBP-1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2006 |
| Target Name | ARID4A |
| Gene ID | 5926,238247,314205,702688,480339,101096240,531515,100051059 |
| Gene Symbol and Synonyms | A630009N03,A630067N03Rik,ARID4A,RBBP-1,RBBP1,RBP-1,RBP1 |
| Uniprot Accession | P29374 |
| Uniprot Entry Name | ARI4A_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000032219 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ARID4A, gene name: ARID4A, also named as RBBP-1, RBBP1, RBP-1, RBP1. The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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