Anti-ARVC/ ARVCF monoclonal antibody

Anti-ARVC/ ARVCF antibody for FACS & in-vivo assay

Target products collectionGo to ARVCF/ARVCF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2009-Ab-1/ GM-Tg-hg-MP2009-Ab-2Anti-Human ARVCF monoclonal antibodyHuman
GM-Tg-rg-MP2009-Ab-1/ GM-Tg-rg-MP2009-Ab-2Anti-Rat ARVCF monoclonal antibodyRat
GM-Tg-mg-MP2009-Ab-1/ GM-Tg-mg-MP2009-Ab-2Anti-Mouse ARVCF monoclonal antibodyMouse
GM-Tg-cynog-MP2009-Ab-1/ GM-Tg-cynog-MP2009-Ab-2Anti-Cynomolgus/ Rhesus macaque ARVCF monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2009-Ab-1/ GM-Tg-felg-MP2009-Ab-2Anti-Feline ARVCF monoclonal antibodyFeline
GM-Tg-cang-MP2009-Ab-1/ GM-Tg-cang-MP2009-Ab-2Anti-Canine ARVCF monoclonal antibodyCanine
GM-Tg-bovg-MP2009-Ab-1/ GM-Tg-bovg-MP2009-Ab-2Anti-Bovine ARVCF monoclonal antibodyBovine
GM-Tg-equg-MP2009-Ab-1/ GM-Tg-equg-MP2009-Ab-2Anti-Equine ARVCF monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2009-Ab-1/ GM-Tg-hg-MP2009-Ab-2; GM-Tg-rg-MP2009-Ab-1/ GM-Tg-rg-MP2009-Ab-2;
GM-Tg-mg-MP2009-Ab-1/ GM-Tg-mg-MP2009-Ab-2; GM-Tg-cynog-MP2009-Ab-1/ GM-Tg-cynog-MP2009-Ab-2;
GM-Tg-felg-MP2009-Ab-1/ GM-Tg-felg-MP2009-Ab-2; GM-Tg-cang-MP2009-Ab-1/ GM-Tg-cang-MP2009-Ab-2;
GM-Tg-bovg-MP2009-Ab-1/ GM-Tg-bovg-MP2009-Ab-2; GM-Tg-equg-MP2009-Ab-1/ GM-Tg-equg-MP2009-Ab-2
Products NameAnti-ARVCF monoclonal antibody
Formatmab
Target NameARVCF
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ARVCF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ARVC/ ARVCF VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001600human ARVCF Lentivirus particle
    ORF Viral VectorpGMLP001600human ARVCF Lentivirus plasmid
    ORF Viral VectorpGMLPm003563mouse Arvcf Lentivirus plasmid
    ORF Viral VectorvGMLPm003563mouse Arvcf Lentivirus particle


    Target information

    Target IDGM-MP2009
    Target NameARVCF
    Gene ID421,11877,303798,712399,486417,101096767,517045,100050796
    Gene Symbol and SynonymsARVCF
    Uniprot AccessionO00192,B4F7F3
    Uniprot Entry NameARVC_HUMAN,B4F7F3_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000099889
    Target ClassificationN/A

    The target: ARVCF, gene name: ARVCF, also named as . Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010].



    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.