Anti-ATP23/ KUB3/ XRCC6BP1 monoclonal antibody

Anti-ATP23/ KUB3/ XRCC6BP1 antibody for FACS & in-vivo assay

Target products collectionGo to ATP23/ATP23 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2011-Ab-1/ GM-Tg-hg-MP2011-Ab-2Anti-Human ATP23 monoclonal antibodyHuman
GM-Tg-rg-MP2011-Ab-1/ GM-Tg-rg-MP2011-Ab-2Anti-Rat ATP23 monoclonal antibodyRat
GM-Tg-mg-MP2011-Ab-1/ GM-Tg-mg-MP2011-Ab-2Anti-Mouse ATP23 monoclonal antibodyMouse
GM-Tg-cynog-MP2011-Ab-1/ GM-Tg-cynog-MP2011-Ab-2Anti-Cynomolgus/ Rhesus macaque ATP23 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2011-Ab-1/ GM-Tg-felg-MP2011-Ab-2Anti-Feline ATP23 monoclonal antibodyFeline
GM-Tg-cang-MP2011-Ab-1/ GM-Tg-cang-MP2011-Ab-2Anti-Canine ATP23 monoclonal antibodyCanine
GM-Tg-bovg-MP2011-Ab-1/ GM-Tg-bovg-MP2011-Ab-2Anti-Bovine ATP23 monoclonal antibodyBovine
GM-Tg-equg-MP2011-Ab-1/ GM-Tg-equg-MP2011-Ab-2Anti-Equine ATP23 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2011-Ab-1/ GM-Tg-hg-MP2011-Ab-2; GM-Tg-rg-MP2011-Ab-1/ GM-Tg-rg-MP2011-Ab-2;
GM-Tg-mg-MP2011-Ab-1/ GM-Tg-mg-MP2011-Ab-2; GM-Tg-cynog-MP2011-Ab-1/ GM-Tg-cynog-MP2011-Ab-2;
GM-Tg-felg-MP2011-Ab-1/ GM-Tg-felg-MP2011-Ab-2; GM-Tg-cang-MP2011-Ab-1/ GM-Tg-cang-MP2011-Ab-2;
GM-Tg-bovg-MP2011-Ab-1/ GM-Tg-bovg-MP2011-Ab-2; GM-Tg-equg-MP2011-Ab-1/ GM-Tg-equg-MP2011-Ab-2
Products NameAnti-ATP23 monoclonal antibody
Formatmab
Target NameATP23
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ATP23 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ATP23/ KUB3/ XRCC6BP1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2011
    Target NameATP23
    Gene ID91419,68876,299828,712932,474422,101083350,514014,100054108
    Gene Symbol and Synonyms1110068E08Rik,2410012H02Rik,ATP23,KUB3,XRCC6BP1
    Uniprot AccessionQ9Y6H3
    Uniprot Entry NameATP23_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000166896
    Target ClassificationN/A

    The target: ATP23, gene name: ATP23, also named as KUB3, XRCC6BP1. The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.