Anti-ATX10/ ATXN10/ E46L monoclonal antibody

Anti-ATX10/ ATXN10/ E46L antibody for FACS & in-vivo assay

Target products collectionGo to ATXN10/ATXN10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2012-Ab-1/ GM-Tg-hg-MP2012-Ab-2Anti-Human ATXN10 monoclonal antibodyHuman
GM-Tg-rg-MP2012-Ab-1/ GM-Tg-rg-MP2012-Ab-2Anti-Rat ATXN10 monoclonal antibodyRat
GM-Tg-mg-MP2012-Ab-1/ GM-Tg-mg-MP2012-Ab-2Anti-Mouse ATXN10 monoclonal antibodyMouse
GM-Tg-cynog-MP2012-Ab-1/ GM-Tg-cynog-MP2012-Ab-2Anti-Cynomolgus/ Rhesus macaque ATXN10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2012-Ab-1/ GM-Tg-felg-MP2012-Ab-2Anti-Feline ATXN10 monoclonal antibodyFeline
GM-Tg-cang-MP2012-Ab-1/ GM-Tg-cang-MP2012-Ab-2Anti-Canine ATXN10 monoclonal antibodyCanine
GM-Tg-bovg-MP2012-Ab-1/ GM-Tg-bovg-MP2012-Ab-2Anti-Bovine ATXN10 monoclonal antibodyBovine
GM-Tg-equg-MP2012-Ab-1/ GM-Tg-equg-MP2012-Ab-2Anti-Equine ATXN10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2012-Ab-1/ GM-Tg-hg-MP2012-Ab-2; GM-Tg-rg-MP2012-Ab-1/ GM-Tg-rg-MP2012-Ab-2;
GM-Tg-mg-MP2012-Ab-1/ GM-Tg-mg-MP2012-Ab-2; GM-Tg-cynog-MP2012-Ab-1/ GM-Tg-cynog-MP2012-Ab-2;
GM-Tg-felg-MP2012-Ab-1/ GM-Tg-felg-MP2012-Ab-2; GM-Tg-cang-MP2012-Ab-1/ GM-Tg-cang-MP2012-Ab-2;
GM-Tg-bovg-MP2012-Ab-1/ GM-Tg-bovg-MP2012-Ab-2; GM-Tg-equg-MP2012-Ab-1/ GM-Tg-equg-MP2012-Ab-2
Products NameAnti-ATXN10 monoclonal antibody
Formatmab
Target NameATXN10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ATXN10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ATX10/ ATXN10/ E46L VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2012
    Target NameATXN10
    Gene ID25814,54138,170821,713805,474467,101095351,767990,100052926
    Gene Symbol and SynonymsATX10,ATXN10,E46,E46L,HUMEEP,SCA10,TEG-169,Tex169
    Uniprot AccessionQ9UBB4,Q9ER24,Q2TBW0
    Uniprot Entry NameATX10_HUMAN,ATX10_RAT,ATX10_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000130638
    Target ClassificationN/A

    The target: ATXN10, gene name: ATXN10, also named as E46L, HUMEEP, SCA10. This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.