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Anti-BAG3/ BAG-3/ BIS monoclonal antibody
Anti-BAG3/ BAG-3/ BIS antibody for FACS & in-vivo assay
Go to BAG3/BAG3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2014-Ab-1/ GM-Tg-hg-MP2014-Ab-2 | Anti-Human BAG3 monoclonal antibody | Human |
| GM-Tg-rg-MP2014-Ab-1/ GM-Tg-rg-MP2014-Ab-2 | Anti-Rat BAG3 monoclonal antibody | Rat |
| GM-Tg-mg-MP2014-Ab-1/ GM-Tg-mg-MP2014-Ab-2 | Anti-Mouse BAG3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2014-Ab-1/ GM-Tg-cynog-MP2014-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BAG3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2014-Ab-1/ GM-Tg-felg-MP2014-Ab-2 | Anti-Feline BAG3 monoclonal antibody | Feline |
| GM-Tg-cang-MP2014-Ab-1/ GM-Tg-cang-MP2014-Ab-2 | Anti-Canine BAG3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2014-Ab-1/ GM-Tg-bovg-MP2014-Ab-2 | Anti-Bovine BAG3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2014-Ab-1/ GM-Tg-equg-MP2014-Ab-2 | Anti-Equine BAG3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2014-Ab-1/ GM-Tg-hg-MP2014-Ab-2; GM-Tg-rg-MP2014-Ab-1/ GM-Tg-rg-MP2014-Ab-2; GM-Tg-mg-MP2014-Ab-1/ GM-Tg-mg-MP2014-Ab-2; GM-Tg-cynog-MP2014-Ab-1/ GM-Tg-cynog-MP2014-Ab-2; GM-Tg-felg-MP2014-Ab-1/ GM-Tg-felg-MP2014-Ab-2; GM-Tg-cang-MP2014-Ab-1/ GM-Tg-cang-MP2014-Ab-2; GM-Tg-bovg-MP2014-Ab-1/ GM-Tg-bovg-MP2014-Ab-2; GM-Tg-equg-MP2014-Ab-1/ GM-Tg-equg-MP2014-Ab-2 |
| Products Name | Anti-BAG3 monoclonal antibody |
| Format | mab |
| Target Name | BAG3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BAG3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species BAG3/ BAG-3/ BIS VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000662 | human BAG3 Lentivirus particle |
| ORF Viral Vector | pGMLP000662 | human BAG3 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000523 | Norway rat Bag3 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000523 | Norway rat Bag3 Adenovirus particle |
Target information
| Target ID | GM-MP2014 |
| Target Name | BAG3 |
| Gene ID | 9531,29810,293524,714420,486916,101094211,782633,100065784 |
| Gene Symbol and Synonyms | BAG-3,BAG3,BIS,CAIR-1,MFM6,mg638 |
| Uniprot Accession | O95817 |
| Uniprot Entry Name | BAG3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000151929 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: BAG3, gene name: BAG3, also named as BAG-3, BIS, CAIR-1, MFM6. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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