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Anti-BCAR1/ CAS/ CAS1 monoclonal antibody
Anti-BCAR1/ CAS/ CAS1 antibody for FACS & in-vivo assay
Go to BCAR1/BCAR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2018-Ab-1/ GM-Tg-hg-MP2018-Ab-2 | Anti-Human BCAR1 monoclonal antibody | Human |
| GM-Tg-rg-MP2018-Ab-1/ GM-Tg-rg-MP2018-Ab-2 | Anti-Rat BCAR1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2018-Ab-1/ GM-Tg-mg-MP2018-Ab-2 | Anti-Mouse BCAR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2018-Ab-1/ GM-Tg-cynog-MP2018-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BCAR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2018-Ab-1/ GM-Tg-felg-MP2018-Ab-2 | Anti-Feline BCAR1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2018-Ab-1/ GM-Tg-cang-MP2018-Ab-2 | Anti-Canine BCAR1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2018-Ab-1/ GM-Tg-bovg-MP2018-Ab-2 | Anti-Bovine BCAR1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2018-Ab-1/ GM-Tg-equg-MP2018-Ab-2 | Anti-Equine BCAR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2018-Ab-1/ GM-Tg-hg-MP2018-Ab-2; GM-Tg-rg-MP2018-Ab-1/ GM-Tg-rg-MP2018-Ab-2; GM-Tg-mg-MP2018-Ab-1/ GM-Tg-mg-MP2018-Ab-2; GM-Tg-cynog-MP2018-Ab-1/ GM-Tg-cynog-MP2018-Ab-2; GM-Tg-felg-MP2018-Ab-1/ GM-Tg-felg-MP2018-Ab-2; GM-Tg-cang-MP2018-Ab-1/ GM-Tg-cang-MP2018-Ab-2; GM-Tg-bovg-MP2018-Ab-1/ GM-Tg-bovg-MP2018-Ab-2; GM-Tg-equg-MP2018-Ab-1/ GM-Tg-equg-MP2018-Ab-2 |
| Products Name | Anti-BCAR1 monoclonal antibody |
| Format | mab |
| Target Name | BCAR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BCAR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species BCAR1/ CAS/ CAS1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2018 |
| Target Name | BCAR1 |
| Gene ID | 9564,12927,25414,713965,479648,101096625,527550,100068908 |
| Gene Symbol and Synonyms | BCAR1,CAS,CAS1,CASS1,CRKAS,P130Cas |
| Uniprot Accession | P56945,Q63767 |
| Uniprot Entry Name | BCAR1_HUMAN,BCAR1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000050820 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: BCAR1, gene name: BCAR1, also named as CAS, CAS1, CASS1, CRKAS, P130Cas. The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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