Anti-BFSP2/ CP47/ CP49 monoclonal antibody

Anti-BFSP2/ CP47/ CP49 antibody for FACS & in-vivo assay

Target products collectionGo to BFSP2/BFSP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2021-Ab-1/ GM-Tg-hg-MP2021-Ab-2Anti-Human BFSP2 monoclonal antibodyHuman
GM-Tg-rg-MP2021-Ab-1/ GM-Tg-rg-MP2021-Ab-2Anti-Rat BFSP2 monoclonal antibodyRat
GM-Tg-mg-MP2021-Ab-1/ GM-Tg-mg-MP2021-Ab-2Anti-Mouse BFSP2 monoclonal antibodyMouse
GM-Tg-cynog-MP2021-Ab-1/ GM-Tg-cynog-MP2021-Ab-2Anti-Cynomolgus/ Rhesus macaque BFSP2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2021-Ab-1/ GM-Tg-felg-MP2021-Ab-2Anti-Feline BFSP2 monoclonal antibodyFeline
GM-Tg-cang-MP2021-Ab-1/ GM-Tg-cang-MP2021-Ab-2Anti-Canine BFSP2 monoclonal antibodyCanine
GM-Tg-bovg-MP2021-Ab-1/ GM-Tg-bovg-MP2021-Ab-2Anti-Bovine BFSP2 monoclonal antibodyBovine
GM-Tg-equg-MP2021-Ab-1/ GM-Tg-equg-MP2021-Ab-2Anti-Equine BFSP2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2021-Ab-1/ GM-Tg-hg-MP2021-Ab-2; GM-Tg-rg-MP2021-Ab-1/ GM-Tg-rg-MP2021-Ab-2;
GM-Tg-mg-MP2021-Ab-1/ GM-Tg-mg-MP2021-Ab-2; GM-Tg-cynog-MP2021-Ab-1/ GM-Tg-cynog-MP2021-Ab-2;
GM-Tg-felg-MP2021-Ab-1/ GM-Tg-felg-MP2021-Ab-2; GM-Tg-cang-MP2021-Ab-1/ GM-Tg-cang-MP2021-Ab-2;
GM-Tg-bovg-MP2021-Ab-1/ GM-Tg-bovg-MP2021-Ab-2; GM-Tg-equg-MP2021-Ab-1/ GM-Tg-equg-MP2021-Ab-2
Products NameAnti-BFSP2 monoclonal antibody
Formatmab
Target NameBFSP2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-BFSP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species BFSP2/ CP47/ CP49 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2021
    Target NameBFSP2
    Gene ID8419,107993,501046,717551,608938,101087862,281645,100065124
    Gene Symbol and SynonymsBFSP2,CP47,CP49,CTRCT12,LIFL-L,PHAKOSIN
    Uniprot AccessionQ13515,D3ZER2,Q28177
    Uniprot Entry NameBFSP2_HUMAN,BFSP2_RAT,BFSP2_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000170819
    Target ClassificationN/A

    The target: BFSP2, gene name: BFSP2, also named as CP47, CP49, CTRCT12, LIFL-L, PHAKOSIN. More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex. [provided by RefSeq, Jun 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.