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Anti-CALD1/ CDM/ H-CAD monoclonal antibody
Anti-CALD1/ CDM/ H-CAD antibody for FACS & in-vivo assay
Go to CALD1/CALD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2031-Ab-1/ GM-Tg-hg-MP2031-Ab-2 | Anti-Human CALD1 monoclonal antibody | Human |
| GM-Tg-rg-MP2031-Ab-1/ GM-Tg-rg-MP2031-Ab-2 | Anti-Rat CALD1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2031-Ab-1/ GM-Tg-mg-MP2031-Ab-2 | Anti-Mouse CALD1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2031-Ab-1/ GM-Tg-cynog-MP2031-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CALD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2031-Ab-1/ GM-Tg-felg-MP2031-Ab-2 | Anti-Feline CALD1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2031-Ab-1/ GM-Tg-cang-MP2031-Ab-2 | Anti-Canine CALD1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2031-Ab-1/ GM-Tg-bovg-MP2031-Ab-2 | Anti-Bovine CALD1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2031-Ab-1/ GM-Tg-equg-MP2031-Ab-2 | Anti-Equine CALD1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2031-Ab-1/ GM-Tg-hg-MP2031-Ab-2; GM-Tg-rg-MP2031-Ab-1/ GM-Tg-rg-MP2031-Ab-2; GM-Tg-mg-MP2031-Ab-1/ GM-Tg-mg-MP2031-Ab-2; GM-Tg-cynog-MP2031-Ab-1/ GM-Tg-cynog-MP2031-Ab-2; GM-Tg-felg-MP2031-Ab-1/ GM-Tg-felg-MP2031-Ab-2; GM-Tg-cang-MP2031-Ab-1/ GM-Tg-cang-MP2031-Ab-2; GM-Tg-bovg-MP2031-Ab-1/ GM-Tg-bovg-MP2031-Ab-2; GM-Tg-equg-MP2031-Ab-1/ GM-Tg-equg-MP2031-Ab-2 |
| Products Name | Anti-CALD1 monoclonal antibody |
| Format | mab |
| Target Name | CALD1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CALD1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CALD1/ CDM/ H-CAD VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001313 | human CALD1 Lentivirus particle |
| ORF Viral Vector | pGMLP001313 | human CALD1 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000167 | human CALD1 Adenovirus particle |
| ORF Viral Vector | pGMAD000167 | human CALD1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002719 | mouse Cald1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002719 | mouse Cald1 Lentivirus particle |
Target information
| Target ID | GM-MP2031 |
| Target Name | CALD1 |
| Gene ID | 800,109624,25687,707050,608135,101095888,281660,100068106 |
| Gene Symbol and Synonyms | 4833423D12Rik,C920027I18Rik,CALD1,caldesmon,CDM,H-CAD,h-CD,HCAD,L-CAD,LCAD,NAG22 |
| Uniprot Accession | Q05682,Q62736,Q27976 |
| Uniprot Entry Name | CALD1_HUMAN,CALD1_RAT,CALD1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000122786 |
| Target Classification | N/A |
The target: CALD1, gene name: CALD1, also named as CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22. This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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