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Anti-CAVN2/ CAVIN2/ PS-p68 monoclonal antibody
Anti-CAVN2/ CAVIN2/ PS-p68 antibody for FACS & in-vivo assay
Go to CAVIN2/CAVIN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2034-Ab-1/ GM-Tg-hg-MP2034-Ab-2 | Anti-Human CAVIN2 monoclonal antibody | Human |
| GM-Tg-rg-MP2034-Ab-1/ GM-Tg-rg-MP2034-Ab-2 | Anti-Rat CAVIN2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2034-Ab-1/ GM-Tg-mg-MP2034-Ab-2 | Anti-Mouse CAVIN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2034-Ab-1/ GM-Tg-cynog-MP2034-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CAVIN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2034-Ab-1/ GM-Tg-felg-MP2034-Ab-2 | Anti-Feline CAVIN2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2034-Ab-1/ GM-Tg-cang-MP2034-Ab-2 | Anti-Canine CAVIN2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2034-Ab-1/ GM-Tg-bovg-MP2034-Ab-2 | Anti-Bovine CAVIN2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2034-Ab-1/ GM-Tg-equg-MP2034-Ab-2 | Anti-Equine CAVIN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2034-Ab-1/ GM-Tg-hg-MP2034-Ab-2; GM-Tg-rg-MP2034-Ab-1/ GM-Tg-rg-MP2034-Ab-2; GM-Tg-mg-MP2034-Ab-1/ GM-Tg-mg-MP2034-Ab-2; GM-Tg-cynog-MP2034-Ab-1/ GM-Tg-cynog-MP2034-Ab-2; GM-Tg-felg-MP2034-Ab-1/ GM-Tg-felg-MP2034-Ab-2; GM-Tg-cang-MP2034-Ab-1/ GM-Tg-cang-MP2034-Ab-2; GM-Tg-bovg-MP2034-Ab-1/ GM-Tg-bovg-MP2034-Ab-2; GM-Tg-equg-MP2034-Ab-1/ GM-Tg-equg-MP2034-Ab-2 |
| Products Name | Anti-CAVIN2 monoclonal antibody |
| Format | mab |
| Target Name | CAVIN2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CAVIN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CAVN2/ CAVIN2/ PS-p68 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002803 | human CAVIN2 Lentivirus particle |
| ORF Viral Vector | pGMLP000146 | human CAVIN2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000146 | human CAVIN2 Lentivirus particle |
| ORF Viral Vector | pGMLP002803 | human CAVIN2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001490 | mouse Cavin2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001490 | mouse Cavin2 Lentivirus particle |
Target information
| Target ID | GM-MP2034 |
| Target Name | CAVIN2 |
| Gene ID | 8436,20324,316384,694299,119867949,101085061,532333,100054790 |
| Gene Symbol and Synonyms | cavin-2,CAVIN2,PS-p68,SDPR,SDR |
| Uniprot Accession | O95810,Q66H98 |
| Uniprot Entry Name | CAVN2_HUMAN,CAVN2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000168497 |
| Target Classification | N/A |
The target: CAVIN2, gene name: CAVIN2, also named as PS-p68, SDPR, SDR, cavin-2. This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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