Anti-CAVN4/ CAVIN4/ MURC monoclonal antibody

Anti-CAVN4/ CAVIN4/ MURC antibody for FACS & in-vivo assay

Target products collectionGo to CAVIN4/CAVIN4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2035-Ab-1/ GM-Tg-hg-MP2035-Ab-2Anti-Human CAVIN4 monoclonal antibodyHuman
GM-Tg-rg-MP2035-Ab-1/ GM-Tg-rg-MP2035-Ab-2Anti-Rat CAVIN4 monoclonal antibodyRat
GM-Tg-mg-MP2035-Ab-1/ GM-Tg-mg-MP2035-Ab-2Anti-Mouse CAVIN4 monoclonal antibodyMouse
GM-Tg-cynog-MP2035-Ab-1/ GM-Tg-cynog-MP2035-Ab-2Anti-Cynomolgus/ Rhesus macaque CAVIN4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2035-Ab-1/ GM-Tg-felg-MP2035-Ab-2Anti-Feline CAVIN4 monoclonal antibodyFeline
GM-Tg-cang-MP2035-Ab-1/ GM-Tg-cang-MP2035-Ab-2Anti-Canine CAVIN4 monoclonal antibodyCanine
GM-Tg-bovg-MP2035-Ab-1/ GM-Tg-bovg-MP2035-Ab-2Anti-Bovine CAVIN4 monoclonal antibodyBovine
GM-Tg-equg-MP2035-Ab-1/ GM-Tg-equg-MP2035-Ab-2Anti-Equine CAVIN4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2035-Ab-1/ GM-Tg-hg-MP2035-Ab-2; GM-Tg-rg-MP2035-Ab-1/ GM-Tg-rg-MP2035-Ab-2;
GM-Tg-mg-MP2035-Ab-1/ GM-Tg-mg-MP2035-Ab-2; GM-Tg-cynog-MP2035-Ab-1/ GM-Tg-cynog-MP2035-Ab-2;
GM-Tg-felg-MP2035-Ab-1/ GM-Tg-felg-MP2035-Ab-2; GM-Tg-cang-MP2035-Ab-1/ GM-Tg-cang-MP2035-Ab-2;
GM-Tg-bovg-MP2035-Ab-1/ GM-Tg-bovg-MP2035-Ab-2; GM-Tg-equg-MP2035-Ab-1/ GM-Tg-equg-MP2035-Ab-2
Products NameAnti-CAVIN4 monoclonal antibody
Formatmab
Target NameCAVIN4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CAVIN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CAVN4/ CAVIN4/ MURC VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm001672mouse Cavin4 Lentivirus plasmid
    ORF Viral VectorvGMLPm001672mouse Cavin4 Lentivirus particle


    Target information

    Target IDGM-MP2035
    Target NameCAVIN4
    Gene ID347273,68016,313225,714379,481632,101086012,528386,100054653
    Gene Symbol and Synonyms2310039E09Rik,cavin-4,CAVIN4,MURC,RGD1310395
    Uniprot AccessionQ5BKX8,B1PRL5,A5PJI6
    Uniprot Entry NameCAVN4_HUMAN,CAVN4_RAT,CAVN4_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000170681
    Target ClassificationN/A

    The target: CAVIN4, gene name: CAVIN4, also named as MURC, cavin-4. This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.