Anti-CCDC8/ 3M3/ PPP1R20 monoclonal antibody

Anti-CCDC8/ 3M3/ PPP1R20 antibody for FACS & in-vivo assay

Target products collectionGo to CCDC8/CCDC8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2039-Ab-1/ GM-Tg-hg-MP2039-Ab-2Anti-Human CCDC8 monoclonal antibodyHuman
GM-Tg-rg-MP2039-Ab-1/ GM-Tg-rg-MP2039-Ab-2Anti-Rat CCDC8 monoclonal antibodyRat
GM-Tg-mg-MP2039-Ab-1/ GM-Tg-mg-MP2039-Ab-2Anti-Mouse CCDC8 monoclonal antibodyMouse
GM-Tg-cynog-MP2039-Ab-1/ GM-Tg-cynog-MP2039-Ab-2Anti-Cynomolgus/ Rhesus macaque CCDC8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2039-Ab-1/ GM-Tg-felg-MP2039-Ab-2Anti-Feline CCDC8 monoclonal antibodyFeline
GM-Tg-cang-MP2039-Ab-1/ GM-Tg-cang-MP2039-Ab-2Anti-Canine CCDC8 monoclonal antibodyCanine
GM-Tg-bovg-MP2039-Ab-1/ GM-Tg-bovg-MP2039-Ab-2Anti-Bovine CCDC8 monoclonal antibodyBovine
GM-Tg-equg-MP2039-Ab-1/ GM-Tg-equg-MP2039-Ab-2Anti-Equine CCDC8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2039-Ab-1/ GM-Tg-hg-MP2039-Ab-2; GM-Tg-rg-MP2039-Ab-1/ GM-Tg-rg-MP2039-Ab-2;
GM-Tg-mg-MP2039-Ab-1/ GM-Tg-mg-MP2039-Ab-2; GM-Tg-cynog-MP2039-Ab-1/ GM-Tg-cynog-MP2039-Ab-2;
GM-Tg-felg-MP2039-Ab-1/ GM-Tg-felg-MP2039-Ab-2; GM-Tg-cang-MP2039-Ab-1/ GM-Tg-cang-MP2039-Ab-2;
GM-Tg-bovg-MP2039-Ab-1/ GM-Tg-bovg-MP2039-Ab-2; GM-Tg-equg-MP2039-Ab-1/ GM-Tg-equg-MP2039-Ab-2
Products NameAnti-CCDC8 monoclonal antibody
Formatmab
Target NameCCDC8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCDC8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CCDC8/ 3M3/ PPP1R20 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm004762mouse Ccdc8 Lentivirus plasmid
    ORF Viral VectorvGMLPm004762mouse Ccdc8 Lentivirus particle


    Target information

    Target IDGM-MP2039
    Target NameCCDC8
    Gene ID83987,434130,494320,716303,484430,101100854,616838,100065813
    Gene Symbol and Synonyms3M3,CCDC8,p90,PPP1R20
    Uniprot AccessionQ9H0W5,P62521
    Uniprot Entry NameCCDC8_HUMAN,CCDC8_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000169515
    Target ClassificationN/A

    The target: CCDC8, gene name: CCDC8, also named as 3M3, PPP1R20, p90. This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.