Anti-CHM2A/ CHMP2A/ BC-2 monoclonal antibody

Anti-CHM2A/ CHMP2A/ BC-2 antibody for FACS & in-vivo assay

Target products collectionGo to CHMP2A/CHMP2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2054-Ab-1/ GM-Tg-hg-MP2054-Ab-2Anti-Human CHMP2A monoclonal antibodyHuman
GM-Tg-rg-MP2054-Ab-1/ GM-Tg-rg-MP2054-Ab-2Anti-Rat CHMP2A monoclonal antibodyRat
GM-Tg-mg-MP2054-Ab-1/ GM-Tg-mg-MP2054-Ab-2Anti-Mouse CHMP2A monoclonal antibodyMouse
GM-Tg-cynog-MP2054-Ab-1/ GM-Tg-cynog-MP2054-Ab-2Anti-Cynomolgus/ Rhesus macaque CHMP2A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2054-Ab-1/ GM-Tg-felg-MP2054-Ab-2Anti-Feline CHMP2A monoclonal antibodyFeline
GM-Tg-cang-MP2054-Ab-1/ GM-Tg-cang-MP2054-Ab-2Anti-Canine CHMP2A monoclonal antibodyCanine
GM-Tg-bovg-MP2054-Ab-1/ GM-Tg-bovg-MP2054-Ab-2Anti-Bovine CHMP2A monoclonal antibodyBovine
GM-Tg-equg-MP2054-Ab-1/ GM-Tg-equg-MP2054-Ab-2Anti-Equine CHMP2A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2054-Ab-1/ GM-Tg-hg-MP2054-Ab-2; GM-Tg-rg-MP2054-Ab-1/ GM-Tg-rg-MP2054-Ab-2;
GM-Tg-mg-MP2054-Ab-1/ GM-Tg-mg-MP2054-Ab-2; GM-Tg-cynog-MP2054-Ab-1/ GM-Tg-cynog-MP2054-Ab-2;
GM-Tg-felg-MP2054-Ab-1/ GM-Tg-felg-MP2054-Ab-2; GM-Tg-cang-MP2054-Ab-1/ GM-Tg-cang-MP2054-Ab-2;
GM-Tg-bovg-MP2054-Ab-1/ GM-Tg-bovg-MP2054-Ab-2; GM-Tg-equg-MP2054-Ab-1/ GM-Tg-equg-MP2054-Ab-2
Products NameAnti-CHMP2A monoclonal antibody
Formatmab
Target NameCHMP2A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CHMP2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CHM2A/ CHMP2A/ BC-2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2054
    Target NameCHMP2A
    Gene ID27243,68953,365191,712059,476364,101085934,523847,100064860
    Gene Symbol and Synonyms1500016L11Rik,BC-2,BC2,CHMP2,CHMP2A,mVps2,RGD1305050,VPS2,VPS2A
    Uniprot AccessionO43633
    Uniprot Entry NameCHM2A_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000130724
    Target ClassificationN/A

    The target: CHMP2A, gene name: CHMP2A, also named as BC-2, BC2, CHMP2, VPS2, VPS2A. CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.