Anti-CLCB/ CLTB/ LCB monoclonal antibody

Anti-CLCB/ CLTB/ LCB antibody for FACS & in-vivo assay

Target products collectionGo to CLTB/CLTB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2058-Ab-1/ GM-Tg-hg-MP2058-Ab-2Anti-Human CLTB monoclonal antibodyHuman
GM-Tg-rg-MP2058-Ab-1/ GM-Tg-rg-MP2058-Ab-2Anti-Rat CLTB monoclonal antibodyRat
GM-Tg-mg-MP2058-Ab-1/ GM-Tg-mg-MP2058-Ab-2Anti-Mouse CLTB monoclonal antibodyMouse
GM-Tg-cynog-MP2058-Ab-1/ GM-Tg-cynog-MP2058-Ab-2Anti-Cynomolgus/ Rhesus macaque CLTB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2058-Ab-1/ GM-Tg-felg-MP2058-Ab-2Anti-Feline CLTB monoclonal antibodyFeline
GM-Tg-cang-MP2058-Ab-1/ GM-Tg-cang-MP2058-Ab-2Anti-Canine CLTB monoclonal antibodyCanine
GM-Tg-bovg-MP2058-Ab-1/ GM-Tg-bovg-MP2058-Ab-2Anti-Bovine CLTB monoclonal antibodyBovine
GM-Tg-equg-MP2058-Ab-1/ GM-Tg-equg-MP2058-Ab-2Anti-Equine CLTB monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2058-Ab-1/ GM-Tg-hg-MP2058-Ab-2; GM-Tg-rg-MP2058-Ab-1/ GM-Tg-rg-MP2058-Ab-2;
GM-Tg-mg-MP2058-Ab-1/ GM-Tg-mg-MP2058-Ab-2; GM-Tg-cynog-MP2058-Ab-1/ GM-Tg-cynog-MP2058-Ab-2;
GM-Tg-felg-MP2058-Ab-1/ GM-Tg-felg-MP2058-Ab-2; GM-Tg-cang-MP2058-Ab-1/ GM-Tg-cang-MP2058-Ab-2;
GM-Tg-bovg-MP2058-Ab-1/ GM-Tg-bovg-MP2058-Ab-2; GM-Tg-equg-MP2058-Ab-1/ GM-Tg-equg-MP2058-Ab-2
Products NameAnti-CLTB monoclonal antibody
Formatmab
Target NameCLTB
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CLTB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CLCB/ CLTB/ LCB VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2058
    Target NameCLTB
    Gene ID1212,74325,116561,702233,489104,101088646,281698,100068882
    Gene Symbol and Synonyms2310046E19Rik,CLTB,CLTLB,LCB
    Uniprot AccessionP09497,P08082,P04975
    Uniprot Entry NameCLCB_HUMAN,CLCB_RAT,CLCB_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000175416
    Target ClassificationN/A

    The target: CLTB, gene name: CLTB, also named as LCB. Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.