Anti-CROCC/ ROLT/ TAX1BP2 monoclonal antibody

Anti-CROCC/ ROLT/ TAX1BP2 antibody for FACS & in-vivo assay

Target products collectionGo to CROCC/CROCC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2067-Ab-1/ GM-Tg-hg-MP2067-Ab-2Anti-Human CROCC monoclonal antibodyHuman
GM-Tg-rg-MP2067-Ab-1/ GM-Tg-rg-MP2067-Ab-2Anti-Rat CROCC monoclonal antibodyRat
GM-Tg-mg-MP2067-Ab-1/ GM-Tg-mg-MP2067-Ab-2Anti-Mouse CROCC monoclonal antibodyMouse
GM-Tg-cynog-MP2067-Ab-1/ GM-Tg-cynog-MP2067-Ab-2Anti-Cynomolgus/ Rhesus macaque CROCC monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2067-Ab-1/ GM-Tg-felg-MP2067-Ab-2Anti-Feline CROCC monoclonal antibodyFeline
GM-Tg-cang-MP2067-Ab-1/ GM-Tg-cang-MP2067-Ab-2Anti-Canine CROCC monoclonal antibodyCanine
GM-Tg-bovg-MP2067-Ab-1/ GM-Tg-bovg-MP2067-Ab-2Anti-Bovine CROCC monoclonal antibodyBovine
GM-Tg-equg-MP2067-Ab-1/ GM-Tg-equg-MP2067-Ab-2Anti-Equine CROCC monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2067-Ab-1/ GM-Tg-hg-MP2067-Ab-2; GM-Tg-rg-MP2067-Ab-1/ GM-Tg-rg-MP2067-Ab-2;
GM-Tg-mg-MP2067-Ab-1/ GM-Tg-mg-MP2067-Ab-2; GM-Tg-cynog-MP2067-Ab-1/ GM-Tg-cynog-MP2067-Ab-2;
GM-Tg-felg-MP2067-Ab-1/ GM-Tg-felg-MP2067-Ab-2; GM-Tg-cang-MP2067-Ab-1/ GM-Tg-cang-MP2067-Ab-2;
GM-Tg-bovg-MP2067-Ab-1/ GM-Tg-bovg-MP2067-Ab-2; GM-Tg-equg-MP2067-Ab-1/ GM-Tg-equg-MP2067-Ab-2
Products NameAnti-CROCC monoclonal antibody
Formatmab
Target NameCROCC
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CROCC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CROCC/ ROLT/ TAX1BP2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2067
    Target NameCROCC
    Gene ID9696,230872,313663,710793,487417,101086242,530641,100147498
    Gene Symbol and SynonymsCROCC,CROCC1,ROLT,TAX1BP2
    Uniprot AccessionQ5TZA2
    Uniprot Entry NameCROCC_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000058453
    Target ClassificationN/A

    The target: CROCC, gene name: CROCC, also named as ROLT, TAX1BP2. Predicted to enable kinesin binding activity and structural molecule activity. Involved in several processes, including centriole-centriole cohesion; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.