Anti-CTND2/ CTNND2/ GT24 monoclonal antibody

Anti-CTND2/ CTNND2/ GT24 antibody for FACS & in-vivo assay

Target products collectionGo to CTNND2/CTNND2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2071-Ab-1/ GM-Tg-hg-MP2071-Ab-2Anti-Human CTNND2 monoclonal antibodyHuman
GM-Tg-rg-MP2071-Ab-1/ GM-Tg-rg-MP2071-Ab-2Anti-Rat CTNND2 monoclonal antibodyRat
GM-Tg-mg-MP2071-Ab-1/ GM-Tg-mg-MP2071-Ab-2Anti-Mouse CTNND2 monoclonal antibodyMouse
GM-Tg-cynog-MP2071-Ab-1/ GM-Tg-cynog-MP2071-Ab-2Anti-Cynomolgus/ Rhesus macaque CTNND2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2071-Ab-1/ GM-Tg-felg-MP2071-Ab-2Anti-Feline CTNND2 monoclonal antibodyFeline
GM-Tg-cang-MP2071-Ab-1/ GM-Tg-cang-MP2071-Ab-2Anti-Canine CTNND2 monoclonal antibodyCanine
GM-Tg-bovg-MP2071-Ab-1/ GM-Tg-bovg-MP2071-Ab-2Anti-Bovine CTNND2 monoclonal antibodyBovine
GM-Tg-equg-MP2071-Ab-1/ GM-Tg-equg-MP2071-Ab-2Anti-Equine CTNND2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2071-Ab-1/ GM-Tg-hg-MP2071-Ab-2; GM-Tg-rg-MP2071-Ab-1/ GM-Tg-rg-MP2071-Ab-2;
GM-Tg-mg-MP2071-Ab-1/ GM-Tg-mg-MP2071-Ab-2; GM-Tg-cynog-MP2071-Ab-1/ GM-Tg-cynog-MP2071-Ab-2;
GM-Tg-felg-MP2071-Ab-1/ GM-Tg-felg-MP2071-Ab-2; GM-Tg-cang-MP2071-Ab-1/ GM-Tg-cang-MP2071-Ab-2;
GM-Tg-bovg-MP2071-Ab-1/ GM-Tg-bovg-MP2071-Ab-2; GM-Tg-equg-MP2071-Ab-1/ GM-Tg-equg-MP2071-Ab-2
Products NameAnti-CTNND2 monoclonal antibody
Formatmab
Target NameCTNND2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CTNND2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CTND2/ CTNND2/ GT24 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2071
    Target NameCTNND2
    Gene ID1501,18163,114028,716900,488048,101092165,523661,100070792
    Gene Symbol and SynonymsCatnd2,CTNND2,GT24,neurojugin,NPRAP
    Uniprot AccessionQ9UQB3,O35116
    Uniprot Entry NameCTND2_HUMAN,CTND2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseIgA glomerulonephritis
    Gene EnsemblENSG00000169862
    Target ClassificationN/A

    The target: CTNND2, gene name: CTNND2, also named as GT24, NPRAP. This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.