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Anti-SRC8/ CTTN/ EMS1 monoclonal antibody
Anti-SRC8/ CTTN/ EMS1 antibody for FACS & in-vivo assay
Go to CTTN/CTTN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2072-Ab-1/ GM-Tg-hg-MP2072-Ab-2 | Anti-Human CTTN monoclonal antibody | Human |
| GM-Tg-rg-MP2072-Ab-1/ GM-Tg-rg-MP2072-Ab-2 | Anti-Rat CTTN monoclonal antibody | Rat |
| GM-Tg-mg-MP2072-Ab-1/ GM-Tg-mg-MP2072-Ab-2 | Anti-Mouse CTTN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2072-Ab-1/ GM-Tg-cynog-MP2072-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CTTN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2072-Ab-1/ GM-Tg-felg-MP2072-Ab-2 | Anti-Feline CTTN monoclonal antibody | Feline |
| GM-Tg-cang-MP2072-Ab-1/ GM-Tg-cang-MP2072-Ab-2 | Anti-Canine CTTN monoclonal antibody | Canine |
| GM-Tg-bovg-MP2072-Ab-1/ GM-Tg-bovg-MP2072-Ab-2 | Anti-Bovine CTTN monoclonal antibody | Bovine |
| GM-Tg-equg-MP2072-Ab-1/ GM-Tg-equg-MP2072-Ab-2 | Anti-Equine CTTN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2072-Ab-1/ GM-Tg-hg-MP2072-Ab-2; GM-Tg-rg-MP2072-Ab-1/ GM-Tg-rg-MP2072-Ab-2; GM-Tg-mg-MP2072-Ab-1/ GM-Tg-mg-MP2072-Ab-2; GM-Tg-cynog-MP2072-Ab-1/ GM-Tg-cynog-MP2072-Ab-2; GM-Tg-felg-MP2072-Ab-1/ GM-Tg-felg-MP2072-Ab-2; GM-Tg-cang-MP2072-Ab-1/ GM-Tg-cang-MP2072-Ab-2; GM-Tg-bovg-MP2072-Ab-1/ GM-Tg-bovg-MP2072-Ab-2; GM-Tg-equg-MP2072-Ab-1/ GM-Tg-equg-MP2072-Ab-2 |
| Products Name | Anti-CTTN monoclonal antibody |
| Format | mab |
| Target Name | CTTN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CTTN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SRC8/ CTTN/ EMS1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003285 | human CTTN Lentivirus particle |
| ORF Viral Vector | pGMLP003285 | human CTTN Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004470 | mouse Cttn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004470 | mouse Cttn Lentivirus particle |
Target information
| Target ID | GM-MP2072 |
| Target Name | CTTN |
| Gene ID | 2017,13043,60465,708291,610283,101088615,506939 |
| Gene Symbol and Synonyms | 1110020L01Rik,CTTN,Cttnb,EMS1 |
| Uniprot Accession | Q14247,Q66HL2 |
| Uniprot Entry Name | SRC8_HUMAN,SRC8_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000085733 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CTTN, gene name: CTTN, also named as EMS1. This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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