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Anti-CYH2/ CYTH2/ ARNO monoclonal antibody
Anti-CYH2/ CYTH2/ ARNO antibody for FACS & in-vivo assay
Go to CYTH2/CYTH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2073-Ab-1/ GM-Tg-hg-MP2073-Ab-2 | Anti-Human CYTH2 monoclonal antibody | Human |
| GM-Tg-rg-MP2073-Ab-1/ GM-Tg-rg-MP2073-Ab-2 | Anti-Rat CYTH2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2073-Ab-1/ GM-Tg-mg-MP2073-Ab-2 | Anti-Mouse CYTH2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2073-Ab-1/ GM-Tg-cynog-MP2073-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYTH2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2073-Ab-1/ GM-Tg-felg-MP2073-Ab-2 | Anti-Feline CYTH2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2073-Ab-1/ GM-Tg-cang-MP2073-Ab-2 | Anti-Canine CYTH2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2073-Ab-1/ GM-Tg-bovg-MP2073-Ab-2 | Anti-Bovine CYTH2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2073-Ab-1/ GM-Tg-equg-MP2073-Ab-2 | Anti-Equine CYTH2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2073-Ab-1/ GM-Tg-hg-MP2073-Ab-2; GM-Tg-rg-MP2073-Ab-1/ GM-Tg-rg-MP2073-Ab-2; GM-Tg-mg-MP2073-Ab-1/ GM-Tg-mg-MP2073-Ab-2; GM-Tg-cynog-MP2073-Ab-1/ GM-Tg-cynog-MP2073-Ab-2; GM-Tg-felg-MP2073-Ab-1/ GM-Tg-felg-MP2073-Ab-2; GM-Tg-cang-MP2073-Ab-1/ GM-Tg-cang-MP2073-Ab-2; GM-Tg-bovg-MP2073-Ab-1/ GM-Tg-bovg-MP2073-Ab-2; GM-Tg-equg-MP2073-Ab-1/ GM-Tg-equg-MP2073-Ab-2 |
| Products Name | Anti-CYTH2 monoclonal antibody |
| Format | mab |
| Target Name | CYTH2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CYTH2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CYH2/ CYTH2/ ARNO VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2073 |
| Target Name | CYTH2 |
| Gene ID | 9266,19158,116692,718682,476423,101089480,768035,100053821 |
| Gene Symbol and Synonyms | ARNO,CLM2,CTS18,CTS18.1,CYTH2,cytohesin-2,PSCD2,PSCD2L,Sec7,Sec7B,SEC7L,Sec7p-L,Sec7p-like |
| Uniprot Accession | Q99418,P63035,Q2KI41 |
| Uniprot Entry Name | CYH2_HUMAN,CYH2_RAT,CYH2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000105443 |
| Target Classification | N/A |
The target: CYTH2, gene name: CYTH2, also named as ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin-2. The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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