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Anti-DAAM1 monoclonal antibody
Anti-DAAM1 antibody for FACS & in-vivo assay
Go to DAAM1/DAAM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2074-Ab-1/ GM-Tg-hg-MP2074-Ab-2 | Anti-Human DAAM1 monoclonal antibody | Human |
| GM-Tg-rg-MP2074-Ab-1/ GM-Tg-rg-MP2074-Ab-2 | Anti-Rat DAAM1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2074-Ab-1/ GM-Tg-mg-MP2074-Ab-2 | Anti-Mouse DAAM1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2074-Ab-1/ GM-Tg-cynog-MP2074-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DAAM1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2074-Ab-1/ GM-Tg-felg-MP2074-Ab-2 | Anti-Feline DAAM1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2074-Ab-1/ GM-Tg-cang-MP2074-Ab-2 | Anti-Canine DAAM1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2074-Ab-1/ GM-Tg-bovg-MP2074-Ab-2 | Anti-Bovine DAAM1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2074-Ab-1/ GM-Tg-equg-MP2074-Ab-2 | Anti-Equine DAAM1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2074-Ab-1/ GM-Tg-hg-MP2074-Ab-2; GM-Tg-rg-MP2074-Ab-1/ GM-Tg-rg-MP2074-Ab-2; GM-Tg-mg-MP2074-Ab-1/ GM-Tg-mg-MP2074-Ab-2; GM-Tg-cynog-MP2074-Ab-1/ GM-Tg-cynog-MP2074-Ab-2; GM-Tg-felg-MP2074-Ab-1/ GM-Tg-felg-MP2074-Ab-2; GM-Tg-cang-MP2074-Ab-1/ GM-Tg-cang-MP2074-Ab-2; GM-Tg-bovg-MP2074-Ab-1/ GM-Tg-bovg-MP2074-Ab-2; GM-Tg-equg-MP2074-Ab-1/ GM-Tg-equg-MP2074-Ab-2 |
| Products Name | Anti-DAAM1 monoclonal antibody |
| Format | mab |
| Target Name | DAAM1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DAAM1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DAAM1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2074 |
| Target Name | DAAM1 |
| Gene ID | 23002,208846,314212,701706,490714,101098546,513742,100051203 |
| Gene Symbol and Synonyms | DAAM1 |
| Uniprot Accession | Q9Y4D1 |
| Uniprot Entry Name | DAAM1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000100592 |
| Target Classification | N/A |
The target: DAAM1, gene name: DAAM1, also named as . Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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