Anti-DREB/ DBN1/ D0S117E monoclonal antibody

Anti-DREB/ DBN1/ D0S117E antibody for FACS & in-vivo assay

Target products collectionGo to DBN1/DBN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2076-Ab-1/ GM-Tg-hg-MP2076-Ab-2Anti-Human DBN1 monoclonal antibodyHuman
GM-Tg-rg-MP2076-Ab-1/ GM-Tg-rg-MP2076-Ab-2Anti-Rat DBN1 monoclonal antibodyRat
GM-Tg-mg-MP2076-Ab-1/ GM-Tg-mg-MP2076-Ab-2Anti-Mouse DBN1 monoclonal antibodyMouse
GM-Tg-cynog-MP2076-Ab-1/ GM-Tg-cynog-MP2076-Ab-2Anti-Cynomolgus/ Rhesus macaque DBN1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2076-Ab-1/ GM-Tg-felg-MP2076-Ab-2Anti-Feline DBN1 monoclonal antibodyFeline
GM-Tg-cang-MP2076-Ab-1/ GM-Tg-cang-MP2076-Ab-2Anti-Canine DBN1 monoclonal antibodyCanine
GM-Tg-bovg-MP2076-Ab-1/ GM-Tg-bovg-MP2076-Ab-2Anti-Bovine DBN1 monoclonal antibodyBovine
GM-Tg-equg-MP2076-Ab-1/ GM-Tg-equg-MP2076-Ab-2Anti-Equine DBN1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2076-Ab-1/ GM-Tg-hg-MP2076-Ab-2; GM-Tg-rg-MP2076-Ab-1/ GM-Tg-rg-MP2076-Ab-2;
GM-Tg-mg-MP2076-Ab-1/ GM-Tg-mg-MP2076-Ab-2; GM-Tg-cynog-MP2076-Ab-1/ GM-Tg-cynog-MP2076-Ab-2;
GM-Tg-felg-MP2076-Ab-1/ GM-Tg-felg-MP2076-Ab-2; GM-Tg-cang-MP2076-Ab-1/ GM-Tg-cang-MP2076-Ab-2;
GM-Tg-bovg-MP2076-Ab-1/ GM-Tg-bovg-MP2076-Ab-2; GM-Tg-equg-MP2076-Ab-1/ GM-Tg-equg-MP2076-Ab-2
Products NameAnti-DBN1 monoclonal antibody
Formatmab
Target NameDBN1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DBN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DREB/ DBN1/ D0S117E VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2076
    Target NameDBN1
    Gene ID1627,56320,81653,700375,489088,493831,505406,100068529
    Gene Symbol and SynonymsD0S117E,DBN1,drebrin
    Uniprot AccessionQ16643,Q07266
    Uniprot Entry NameDREB_HUMAN,DREB_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseProstate Cancer
    Gene EnsemblENSG00000113758
    Target ClassificationN/A

    The target: DBN1, gene name: DBN1, also named as D0S117E. The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.