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Anti-ERBIN/ ERBB2IP/ HEL-S-78 monoclonal antibody
Anti-ERBIN/ ERBB2IP/ HEL-S-78 antibody for FACS & in-vivo assay
Go to ERBIN/ERBIN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2112-Ab-1/ GM-Tg-hg-MP2112-Ab-2 | Anti-Human ERBIN monoclonal antibody | Human |
| GM-Tg-rg-MP2112-Ab-1/ GM-Tg-rg-MP2112-Ab-2 | Anti-Rat ERBIN monoclonal antibody | Rat |
| GM-Tg-mg-MP2112-Ab-1/ GM-Tg-mg-MP2112-Ab-2 | Anti-Mouse ERBIN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2112-Ab-1/ GM-Tg-cynog-MP2112-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ERBIN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2112-Ab-1/ GM-Tg-felg-MP2112-Ab-2 | Anti-Feline ERBIN monoclonal antibody | Feline |
| GM-Tg-cang-MP2112-Ab-1/ GM-Tg-cang-MP2112-Ab-2 | Anti-Canine ERBIN monoclonal antibody | Canine |
| GM-Tg-bovg-MP2112-Ab-1/ GM-Tg-bovg-MP2112-Ab-2 | Anti-Bovine ERBIN monoclonal antibody | Bovine |
| GM-Tg-equg-MP2112-Ab-1/ GM-Tg-equg-MP2112-Ab-2 | Anti-Equine ERBIN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2112-Ab-1/ GM-Tg-hg-MP2112-Ab-2; GM-Tg-rg-MP2112-Ab-1/ GM-Tg-rg-MP2112-Ab-2; GM-Tg-mg-MP2112-Ab-1/ GM-Tg-mg-MP2112-Ab-2; GM-Tg-cynog-MP2112-Ab-1/ GM-Tg-cynog-MP2112-Ab-2; GM-Tg-felg-MP2112-Ab-1/ GM-Tg-felg-MP2112-Ab-2; GM-Tg-cang-MP2112-Ab-1/ GM-Tg-cang-MP2112-Ab-2; GM-Tg-bovg-MP2112-Ab-1/ GM-Tg-bovg-MP2112-Ab-2; GM-Tg-equg-MP2112-Ab-1/ GM-Tg-equg-MP2112-Ab-2 |
| Products Name | Anti-ERBIN monoclonal antibody |
| Format | mab |
| Target Name | ERBIN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ERBIN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ERBIN/ ERBB2IP/ HEL-S-78 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2112 |
| Target Name | ERBIN |
| Gene ID | 55914,59079,365661,700429,100856182,101083061,512866,100057128 |
| Gene Symbol and Synonyms | 1700028E05Rik,Erbb2i,ERBB2IP,ERBIN,HEL-S-78,LAP2,mKIAA1225,RGD1562952 |
| Uniprot Accession | Q96RT1 |
| Uniprot Entry Name | ERBIN_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000112851 |
| Target Classification | N/A |
The target: ERBIN, gene name: ERBIN, also named as ERBB2IP, HEL-S-78, LAP2. This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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