Anti-FLIP1/ FILIP1/ FILIP monoclonal antibody

Anti-FLIP1/ FILIP1/ FILIP antibody for FACS & in-vivo assay

Target products collectionGo to FILIP1/FILIP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2123-Ab-1/ GM-Tg-hg-MP2123-Ab-2Anti-Human FILIP1 monoclonal antibodyHuman
GM-Tg-rg-MP2123-Ab-1/ GM-Tg-rg-MP2123-Ab-2Anti-Rat FILIP1 monoclonal antibodyRat
GM-Tg-mg-MP2123-Ab-1/ GM-Tg-mg-MP2123-Ab-2Anti-Mouse FILIP1 monoclonal antibodyMouse
GM-Tg-cynog-MP2123-Ab-1/ GM-Tg-cynog-MP2123-Ab-2Anti-Cynomolgus/ Rhesus macaque FILIP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2123-Ab-1/ GM-Tg-felg-MP2123-Ab-2Anti-Feline FILIP1 monoclonal antibodyFeline
GM-Tg-cang-MP2123-Ab-1/ GM-Tg-cang-MP2123-Ab-2Anti-Canine FILIP1 monoclonal antibodyCanine
GM-Tg-bovg-MP2123-Ab-1/ GM-Tg-bovg-MP2123-Ab-2Anti-Bovine FILIP1 monoclonal antibodyBovine
GM-Tg-equg-MP2123-Ab-1/ GM-Tg-equg-MP2123-Ab-2Anti-Equine FILIP1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2123-Ab-1/ GM-Tg-hg-MP2123-Ab-2; GM-Tg-rg-MP2123-Ab-1/ GM-Tg-rg-MP2123-Ab-2;
GM-Tg-mg-MP2123-Ab-1/ GM-Tg-mg-MP2123-Ab-2; GM-Tg-cynog-MP2123-Ab-1/ GM-Tg-cynog-MP2123-Ab-2;
GM-Tg-felg-MP2123-Ab-1/ GM-Tg-felg-MP2123-Ab-2; GM-Tg-cang-MP2123-Ab-1/ GM-Tg-cang-MP2123-Ab-2;
GM-Tg-bovg-MP2123-Ab-1/ GM-Tg-bovg-MP2123-Ab-2; GM-Tg-equg-MP2123-Ab-1/ GM-Tg-equg-MP2123-Ab-2
Products NameAnti-FILIP1 monoclonal antibody
Formatmab
Target NameFILIP1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FILIP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species FLIP1/ FILIP1/ FILIP VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2123
    Target NameFILIP1
    Gene ID27145,70598,246776,716439,119881677,101094101,514193,100065183
    Gene Symbol and Synonyms5730485H21Rik,FILIP,FILIP1,LOC119881677
    Uniprot AccessionQ7Z7B0,Q8K4T4
    Uniprot Entry NameFLIP1_HUMAN,FLIP1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000118407
    Target ClassificationN/A

    The target: FILIP1, gene name: FILIP1, also named as FILIP. This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.