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Anti-FLNC/ ABP-280/ ABP280A monoclonal antibody
Anti-FLNC/ ABP-280/ ABP280A antibody for FACS & in-vivo assay
Go to FLNC/FLNC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2127-Ab-1/ GM-Tg-hg-MP2127-Ab-2 | Anti-Human FLNC monoclonal antibody | Human |
| GM-Tg-rg-MP2127-Ab-1/ GM-Tg-rg-MP2127-Ab-2 | Anti-Rat FLNC monoclonal antibody | Rat |
| GM-Tg-mg-MP2127-Ab-1/ GM-Tg-mg-MP2127-Ab-2 | Anti-Mouse FLNC monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2127-Ab-1/ GM-Tg-cynog-MP2127-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FLNC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2127-Ab-1/ GM-Tg-felg-MP2127-Ab-2 | Anti-Feline FLNC monoclonal antibody | Feline |
| GM-Tg-cang-MP2127-Ab-1/ GM-Tg-cang-MP2127-Ab-2 | Anti-Canine FLNC monoclonal antibody | Canine |
| GM-Tg-bovg-MP2127-Ab-1/ GM-Tg-bovg-MP2127-Ab-2 | Anti-Bovine FLNC monoclonal antibody | Bovine |
| GM-Tg-equg-MP2127-Ab-1/ GM-Tg-equg-MP2127-Ab-2 | Anti-Equine FLNC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2127-Ab-1/ GM-Tg-hg-MP2127-Ab-2; GM-Tg-rg-MP2127-Ab-1/ GM-Tg-rg-MP2127-Ab-2; GM-Tg-mg-MP2127-Ab-1/ GM-Tg-mg-MP2127-Ab-2; GM-Tg-cynog-MP2127-Ab-1/ GM-Tg-cynog-MP2127-Ab-2; GM-Tg-felg-MP2127-Ab-1/ GM-Tg-felg-MP2127-Ab-2; GM-Tg-cang-MP2127-Ab-1/ GM-Tg-cang-MP2127-Ab-2; GM-Tg-bovg-MP2127-Ab-1/ GM-Tg-bovg-MP2127-Ab-2; GM-Tg-equg-MP2127-Ab-1/ GM-Tg-equg-MP2127-Ab-2 |
| Products Name | Anti-FLNC monoclonal antibody |
| Format | mab |
| Target Name | FLNC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FLNC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FLNC/ ABP-280/ ABP280A VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP2127 |
| Target Name | FLNC |
| Gene ID | 2318,68794,362332,700223,482266,101081210,528415,100071760 |
| Gene Symbol and Synonyms | 1110055E19Rik,ABP-280,ABP-L,ABP280A,ABPA,ABPL,ARVC15,CMH26,FLN-C,FLN2,FLNC,MFM5,MPD4,RCM5 |
| Uniprot Accession | Q14315,D3ZHA0 |
| Uniprot Entry Name | FLNC_HUMAN,FLNC_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer, Mucocutaneous lymph node syndrome [Kawasaki] |
| Gene Ensembl | ENSG00000128591 |
| Target Classification | N/A |
The target: FLNC, gene name: FLNC, also named as ABP-280, ABP280A, ABPA, ABPL, CMH26, FLN2, MFM5, MPD4, RCM5. This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Mutations in this gene are a cause of cardiopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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