Anti-FLOT1 monoclonal antibody

Anti-FLOT1 antibody for FACS & in-vivo assay

Target products collectionGo to FLOT1/FLOT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2128-Ab-1/ GM-Tg-hg-MP2128-Ab-2Anti-Human FLOT1 monoclonal antibodyHuman
GM-Tg-rg-MP2128-Ab-1/ GM-Tg-rg-MP2128-Ab-2Anti-Rat FLOT1 monoclonal antibodyRat
GM-Tg-mg-MP2128-Ab-1/ GM-Tg-mg-MP2128-Ab-2Anti-Mouse FLOT1 monoclonal antibodyMouse
GM-Tg-cynog-MP2128-Ab-1/ GM-Tg-cynog-MP2128-Ab-2Anti-Cynomolgus/ Rhesus macaque FLOT1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2128-Ab-1/ GM-Tg-felg-MP2128-Ab-2Anti-Feline FLOT1 monoclonal antibodyFeline
GM-Tg-cang-MP2128-Ab-1/ GM-Tg-cang-MP2128-Ab-2Anti-Canine FLOT1 monoclonal antibodyCanine
GM-Tg-bovg-MP2128-Ab-1/ GM-Tg-bovg-MP2128-Ab-2Anti-Bovine FLOT1 monoclonal antibodyBovine
GM-Tg-equg-MP2128-Ab-1/ GM-Tg-equg-MP2128-Ab-2Anti-Equine FLOT1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2128-Ab-1/ GM-Tg-hg-MP2128-Ab-2; GM-Tg-rg-MP2128-Ab-1/ GM-Tg-rg-MP2128-Ab-2;
GM-Tg-mg-MP2128-Ab-1/ GM-Tg-mg-MP2128-Ab-2; GM-Tg-cynog-MP2128-Ab-1/ GM-Tg-cynog-MP2128-Ab-2;
GM-Tg-felg-MP2128-Ab-1/ GM-Tg-felg-MP2128-Ab-2; GM-Tg-cang-MP2128-Ab-1/ GM-Tg-cang-MP2128-Ab-2;
GM-Tg-bovg-MP2128-Ab-1/ GM-Tg-bovg-MP2128-Ab-2; GM-Tg-equg-MP2128-Ab-1/ GM-Tg-equg-MP2128-Ab-2
Products NameAnti-FLOT1 monoclonal antibody
Formatmab
Target NameFLOT1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FLOT1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species FLOT1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003834human FLOT1 Lentivirus plasmid
    ORF Viral VectorvGMLP003834human FLOT1 Lentivirus particle


    Target information

    Target IDGM-MP2128
    Target NameFLOT1
    Gene ID10211,14251,64665,714175,474831,101096063,532573,100050936
    Gene Symbol and SynonymsFLOT1,Rareg,reggie-2
    Uniprot AccessionO75955,Q9Z1E1,Q5™70,Q08DN8
    Uniprot Entry NameFLOT1_HUMAN,FLOT1_MACMU,FLOT1_RAT,FLOT1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseMalignant neoplasm of prostate
    Gene EnsemblENSG00000137312
    Target ClassificationN/A

    The target: FLOT1, gene name: FLOT1, also named as . This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.