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Anti-GAB2 monoclonal antibody
Anti-GAB2 antibody for FACS & in-vivo assay
Go to GAB2/GAB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2135-Ab-1/ GM-Tg-hg-MP2135-Ab-2 | Anti-Human GAB2 monoclonal antibody | Human |
| GM-Tg-rg-MP2135-Ab-1/ GM-Tg-rg-MP2135-Ab-2 | Anti-Rat GAB2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2135-Ab-1/ GM-Tg-mg-MP2135-Ab-2 | Anti-Mouse GAB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2135-Ab-1/ GM-Tg-cynog-MP2135-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GAB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2135-Ab-1/ GM-Tg-felg-MP2135-Ab-2 | Anti-Feline GAB2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2135-Ab-1/ GM-Tg-cang-MP2135-Ab-2 | Anti-Canine GAB2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2135-Ab-1/ GM-Tg-bovg-MP2135-Ab-2 | Anti-Bovine GAB2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2135-Ab-1/ GM-Tg-equg-MP2135-Ab-2 | Anti-Equine GAB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2135-Ab-1/ GM-Tg-hg-MP2135-Ab-2; GM-Tg-rg-MP2135-Ab-1/ GM-Tg-rg-MP2135-Ab-2; GM-Tg-mg-MP2135-Ab-1/ GM-Tg-mg-MP2135-Ab-2; GM-Tg-cynog-MP2135-Ab-1/ GM-Tg-cynog-MP2135-Ab-2; GM-Tg-felg-MP2135-Ab-1/ GM-Tg-felg-MP2135-Ab-2; GM-Tg-cang-MP2135-Ab-1/ GM-Tg-cang-MP2135-Ab-2; GM-Tg-bovg-MP2135-Ab-1/ GM-Tg-bovg-MP2135-Ab-2; GM-Tg-equg-MP2135-Ab-1/ GM-Tg-equg-MP2135-Ab-2 |
| Products Name | Anti-GAB2 monoclonal antibody |
| Format | mab |
| Target Name | GAB2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GAB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GAB2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP000244 | human GAB2 Lentivirus particle |
| ORF Viral Vector | pGMLP000244 | human GAB2 Lentivirus plasmid |
Target information
| Target ID | GM-MP2135 |
| Target Name | GAB2 |
| Gene ID | 9846,14389,84477,700197,485167,101101410,529346,100062877 |
| Gene Symbol and Synonyms | D130058I17Rik,GAB2,p97 |
| Uniprot Accession | Q9UQC2,Q9EQH1 |
| Uniprot Entry Name | GAB2_HUMAN,GAB2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000033327 |
| Target Classification | N/A |
The target: GAB2, gene name: GAB2, also named as . This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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