Anti-DRC4/ GAS8/ CILD33 monoclonal antibody

Anti-DRC4/ GAS8/ CILD33 antibody for FACS & in-vivo assay

Target products collectionGo to GAS8/GAS8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2138-Ab-1/ GM-Tg-hg-MP2138-Ab-2Anti-Human GAS8 monoclonal antibodyHuman
GM-Tg-rg-MP2138-Ab-1/ GM-Tg-rg-MP2138-Ab-2Anti-Rat GAS8 monoclonal antibodyRat
GM-Tg-mg-MP2138-Ab-1/ GM-Tg-mg-MP2138-Ab-2Anti-Mouse GAS8 monoclonal antibodyMouse
GM-Tg-cynog-MP2138-Ab-1/ GM-Tg-cynog-MP2138-Ab-2Anti-Cynomolgus/ Rhesus macaque GAS8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2138-Ab-1/ GM-Tg-felg-MP2138-Ab-2Anti-Feline GAS8 monoclonal antibodyFeline
GM-Tg-cang-MP2138-Ab-1/ GM-Tg-cang-MP2138-Ab-2Anti-Canine GAS8 monoclonal antibodyCanine
GM-Tg-bovg-MP2138-Ab-1/ GM-Tg-bovg-MP2138-Ab-2Anti-Bovine GAS8 monoclonal antibodyBovine
GM-Tg-equg-MP2138-Ab-1/ GM-Tg-equg-MP2138-Ab-2Anti-Equine GAS8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2138-Ab-1/ GM-Tg-hg-MP2138-Ab-2; GM-Tg-rg-MP2138-Ab-1/ GM-Tg-rg-MP2138-Ab-2;
GM-Tg-mg-MP2138-Ab-1/ GM-Tg-mg-MP2138-Ab-2; GM-Tg-cynog-MP2138-Ab-1/ GM-Tg-cynog-MP2138-Ab-2;
GM-Tg-felg-MP2138-Ab-1/ GM-Tg-felg-MP2138-Ab-2; GM-Tg-cang-MP2138-Ab-1/ GM-Tg-cang-MP2138-Ab-2;
GM-Tg-bovg-MP2138-Ab-1/ GM-Tg-bovg-MP2138-Ab-2; GM-Tg-equg-MP2138-Ab-1/ GM-Tg-equg-MP2138-Ab-2
Products NameAnti-GAS8 monoclonal antibody
Formatmab
Target NameGAS8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GAS8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DRC4/ GAS8/ CILD33 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm003271mouse Gas8 Lentivirus plasmid
    ORF Viral VectorvGMLPm003271mouse Gas8 Lentivirus particle


    Target information

    Target IDGM-MP2138
    Target NameGAS8
    Gene ID2622,104346,361438,701458,608663,101084502,504318,100052980
    Gene Symbol and SynonymsCILD33,DRC4,GAS11,GAS8
    Uniprot AccessionO95995,Q499U4,A5D7M3
    Uniprot Entry NameDRC4_HUMAN,DRC4_RAT,DRC4_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000141013
    Target ClassificationN/A

    The target: GAS8, gene name: GAS8, also named as CILD33, DRC4, GAS11. This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.