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Anti-GBB1/ GNB1/ MRD42 monoclonal antibody
Anti-GBB1/ GNB1/ MRD42 antibody for FACS & in-vivo assay
Go to GNB1/GNB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2145-Ab-1/ GM-Tg-hg-MP2145-Ab-2 | Anti-Human GNB1 monoclonal antibody | Human |
| GM-Tg-rg-MP2145-Ab-1/ GM-Tg-rg-MP2145-Ab-2 | Anti-Rat GNB1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2145-Ab-1/ GM-Tg-mg-MP2145-Ab-2 | Anti-Mouse GNB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2145-Ab-1/ GM-Tg-cynog-MP2145-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GNB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2145-Ab-1/ GM-Tg-felg-MP2145-Ab-2 | Anti-Feline GNB1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2145-Ab-1/ GM-Tg-cang-MP2145-Ab-2 | Anti-Canine GNB1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2145-Ab-1/ GM-Tg-bovg-MP2145-Ab-2 | Anti-Bovine GNB1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2145-Ab-1/ GM-Tg-equg-MP2145-Ab-2 | Anti-Equine GNB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2145-Ab-1/ GM-Tg-hg-MP2145-Ab-2; GM-Tg-rg-MP2145-Ab-1/ GM-Tg-rg-MP2145-Ab-2; GM-Tg-mg-MP2145-Ab-1/ GM-Tg-mg-MP2145-Ab-2; GM-Tg-cynog-MP2145-Ab-1/ GM-Tg-cynog-MP2145-Ab-2; GM-Tg-felg-MP2145-Ab-1/ GM-Tg-felg-MP2145-Ab-2; GM-Tg-cang-MP2145-Ab-1/ GM-Tg-cang-MP2145-Ab-2; GM-Tg-bovg-MP2145-Ab-1/ GM-Tg-bovg-MP2145-Ab-2; GM-Tg-equg-MP2145-Ab-1/ GM-Tg-equg-MP2145-Ab-2 |
| Products Name | Anti-GNB1 monoclonal antibody |
| Format | mab |
| Target Name | GNB1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GNB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GBB1/ GNB1/ MRD42 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000388 | Human GNB1 Adenovirus particle |
| ORF Viral Vector | pGMAP000388 | Human GNB1 Adenovirus plasmid |
| ORF Viral Vector | pGMAP000170 | Human GNB1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000170 | Human GNB1 Adenovirus particle |
| ORF Viral Vector | pGMLPm001420 | mouse Gnb1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001420 | mouse Gnb1 Lentivirus particle |
Target information
| Target ID | GM-MP2145 |
| Target Name | GNB1 |
| Gene ID | 2782,14688,24400,703399,403912,101086580,281201,100061395 |
| Gene Symbol and Synonyms | Gnb-1,GNB1,HG2A,MDS,MRD42 |
| Uniprot Accession | P62873,P54311,P62872,P62871 |
| Uniprot Entry Name | GBB1_HUMAN,GBB1_RAT,GBB1_CANLF,GBB1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000078369 |
| Target Classification | N/A |
The target: GNB1, gene name: GNB1, also named as MRD42. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
