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Anti-GRAP2/ GADS/ GRAP-2 monoclonal antibody
Anti-GRAP2/ GADS/ GRAP-2 antibody for FACS & in-vivo assay
Go to GRAP2/GRAP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2151-Ab-1/ GM-Tg-hg-MP2151-Ab-2 | Anti-Human GRAP2 monoclonal antibody | Human |
| GM-Tg-rg-MP2151-Ab-1/ GM-Tg-rg-MP2151-Ab-2 | Anti-Rat GRAP2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2151-Ab-1/ GM-Tg-mg-MP2151-Ab-2 | Anti-Mouse GRAP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2151-Ab-1/ GM-Tg-cynog-MP2151-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GRAP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2151-Ab-1/ GM-Tg-felg-MP2151-Ab-2 | Anti-Feline GRAP2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2151-Ab-1/ GM-Tg-cang-MP2151-Ab-2 | Anti-Canine GRAP2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2151-Ab-1/ GM-Tg-bovg-MP2151-Ab-2 | Anti-Bovine GRAP2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2151-Ab-1/ GM-Tg-equg-MP2151-Ab-2 | Anti-Equine GRAP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2151-Ab-1/ GM-Tg-hg-MP2151-Ab-2; GM-Tg-rg-MP2151-Ab-1/ GM-Tg-rg-MP2151-Ab-2; GM-Tg-mg-MP2151-Ab-1/ GM-Tg-mg-MP2151-Ab-2; GM-Tg-cynog-MP2151-Ab-1/ GM-Tg-cynog-MP2151-Ab-2; GM-Tg-felg-MP2151-Ab-1/ GM-Tg-felg-MP2151-Ab-2; GM-Tg-cang-MP2151-Ab-1/ GM-Tg-cang-MP2151-Ab-2; GM-Tg-bovg-MP2151-Ab-1/ GM-Tg-bovg-MP2151-Ab-2; GM-Tg-equg-MP2151-Ab-1/ GM-Tg-equg-MP2151-Ab-2 |
| Products Name | Anti-GRAP2 monoclonal antibody |
| Format | mab |
| Target Name | GRAP2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GRAP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GRAP2/ GADS/ GRAP-2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002109 | human GRAP2 Lentivirus particle |
| ORF Viral Vector | pGMLP002109 | human GRAP2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000379 | mouse Grap2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000379 | mouse Grap2 Lentivirus particle |
Target information
| Target ID | GM-MP2151 |
| Target Name | GRAP2 |
| Gene ID | 9402,17444,366962,704410,481241,101084554,522346,100055418 |
| Gene Symbol and Synonyms | GADS,GRAP-2,GRAP2,GRB2L,GRBLG,GrbX,Grf40,GRID,GRPL,Mona,P38 |
| Uniprot Accession | O75791 |
| Uniprot Entry Name | GRAP2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | IgA glomerulonephritis |
| Gene Ensembl | ENSG00000100351 |
| Target Classification | N/A |
The target: GRAP2, gene name: GRAP2, also named as GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38. This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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