Anti-HERC2/ D15F37S1/ MRT38 monoclonal antibody

Anti-HERC2/ D15F37S1/ MRT38 antibody for FACS & in-vivo assay

Target products collectionGo to HERC2/HERC2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2158-Ab-1/ GM-Tg-hg-MP2158-Ab-2Anti-Human HERC2 monoclonal antibodyHuman
GM-Tg-rg-MP2158-Ab-1/ GM-Tg-rg-MP2158-Ab-2Anti-Rat HERC2 monoclonal antibodyRat
GM-Tg-mg-MP2158-Ab-1/ GM-Tg-mg-MP2158-Ab-2Anti-Mouse HERC2 monoclonal antibodyMouse
GM-Tg-cynog-MP2158-Ab-1/ GM-Tg-cynog-MP2158-Ab-2Anti-Cynomolgus/ Rhesus macaque HERC2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2158-Ab-1/ GM-Tg-felg-MP2158-Ab-2Anti-Feline HERC2 monoclonal antibodyFeline
GM-Tg-cang-MP2158-Ab-1/ GM-Tg-cang-MP2158-Ab-2Anti-Canine HERC2 monoclonal antibodyCanine
GM-Tg-bovg-MP2158-Ab-1/ GM-Tg-bovg-MP2158-Ab-2Anti-Bovine HERC2 monoclonal antibodyBovine
GM-Tg-equg-MP2158-Ab-1/ GM-Tg-equg-MP2158-Ab-2Anti-Equine HERC2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2158-Ab-1/ GM-Tg-hg-MP2158-Ab-2; GM-Tg-rg-MP2158-Ab-1/ GM-Tg-rg-MP2158-Ab-2;
GM-Tg-mg-MP2158-Ab-1/ GM-Tg-mg-MP2158-Ab-2; GM-Tg-cynog-MP2158-Ab-1/ GM-Tg-cynog-MP2158-Ab-2;
GM-Tg-felg-MP2158-Ab-1/ GM-Tg-felg-MP2158-Ab-2; GM-Tg-cang-MP2158-Ab-1/ GM-Tg-cang-MP2158-Ab-2;
GM-Tg-bovg-MP2158-Ab-1/ GM-Tg-bovg-MP2158-Ab-2; GM-Tg-equg-MP2158-Ab-1/ GM-Tg-equg-MP2158-Ab-2
Products NameAnti-HERC2 monoclonal antibody
Formatmab
Target NameHERC2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HERC2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HERC2/ D15F37S1/ MRT38 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2158
    Target NameHERC2
    Gene ID8924,15204,308669,479005,101091789,535440,100050955
    Gene Symbol and SynonymsD15F32S1h,D15F37S1,D7H15F32S1,D7H15F37S1,HERC2,jdf2,mKIAA0393,MRT38,p528,rjs,SHEP1
    Uniprot AccessionO95714
    Uniprot Entry NameHERC2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000128731
    Target ClassificationN/A

    The target: HERC2, gene name: HERC2, also named as D15F37S1, MRT38, SHEP1, jdf2, p528. This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.