Anti-IFIT5/ ISG58/ P58 monoclonal antibody

Anti-IFIT5/ ISG58/ P58 antibody for FACS & in-vivo assay

Target products collectionGo to IFIT5/IFIT5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2164-Ab-1/ GM-Tg-hg-MP2164-Ab-2Anti-Human IFIT5 monoclonal antibodyHuman
GM-Tg-rg-MP2164-Ab-1/ GM-Tg-rg-MP2164-Ab-2Anti-Rat IFIT5 monoclonal antibodyRat
GM-Tg-mg-MP2164-Ab-1/ GM-Tg-mg-MP2164-Ab-2Anti-Mouse IFIT5 monoclonal antibodyMouse
GM-Tg-cynog-MP2164-Ab-1/ GM-Tg-cynog-MP2164-Ab-2Anti-Cynomolgus/ Rhesus macaque IFIT5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2164-Ab-1/ GM-Tg-felg-MP2164-Ab-2Anti-Feline IFIT5 monoclonal antibodyFeline
GM-Tg-cang-MP2164-Ab-1/ GM-Tg-cang-MP2164-Ab-2Anti-Canine IFIT5 monoclonal antibodyCanine
GM-Tg-bovg-MP2164-Ab-1/ GM-Tg-bovg-MP2164-Ab-2Anti-Bovine IFIT5 monoclonal antibodyBovine
GM-Tg-equg-MP2164-Ab-1/ GM-Tg-equg-MP2164-Ab-2Anti-Equine IFIT5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2164-Ab-1/ GM-Tg-hg-MP2164-Ab-2; GM-Tg-rg-MP2164-Ab-1/ GM-Tg-rg-MP2164-Ab-2;
GM-Tg-mg-MP2164-Ab-1/ GM-Tg-mg-MP2164-Ab-2; GM-Tg-cynog-MP2164-Ab-1/ GM-Tg-cynog-MP2164-Ab-2;
GM-Tg-felg-MP2164-Ab-1/ GM-Tg-felg-MP2164-Ab-2; GM-Tg-cang-MP2164-Ab-1/ GM-Tg-cang-MP2164-Ab-2;
GM-Tg-bovg-MP2164-Ab-1/ GM-Tg-bovg-MP2164-Ab-2; GM-Tg-equg-MP2164-Ab-1/ GM-Tg-equg-MP2164-Ab-2
Products NameAnti-IFIT5 monoclonal antibody
Formatmab
Target NameIFIT5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IFIT5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species IFIT5/ ISG58/ P58 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP003752human IFIT5 Lentivirus particle
    ORF Viral VectorpGMLP003752human IFIT5 Lentivirus plasmid


    Target information

    Target IDGM-MP2164
    Target NameIFIT5
    Gene ID24138,695796,486788,101082949,515091
    Gene Symbol and SynonymsIFIT5,ISG58,P58,RI58
    Uniprot AccessionQ13325
    Uniprot Entry NameIFIT5_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000152778
    Target ClassificationN/A

    The target: IFIT5, gene name: IFIT5, also named as ISG58, P58, RI58. Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.