Anti-IQGA1/ IQGAP1/ HUMORFA01 monoclonal antibody

Anti-IQGA1/ IQGAP1/ HUMORFA01 antibody for FACS & in-vivo assay

Target products collectionGo to IQGAP1/IQGAP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2166-Ab-1/ GM-Tg-hg-MP2166-Ab-2Anti-Human IQGAP1 monoclonal antibodyHuman
GM-Tg-rg-MP2166-Ab-1/ GM-Tg-rg-MP2166-Ab-2Anti-Rat IQGAP1 monoclonal antibodyRat
GM-Tg-mg-MP2166-Ab-1/ GM-Tg-mg-MP2166-Ab-2Anti-Mouse IQGAP1 monoclonal antibodyMouse
GM-Tg-cynog-MP2166-Ab-1/ GM-Tg-cynog-MP2166-Ab-2Anti-Cynomolgus/ Rhesus macaque IQGAP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2166-Ab-1/ GM-Tg-felg-MP2166-Ab-2Anti-Feline IQGAP1 monoclonal antibodyFeline
GM-Tg-cang-MP2166-Ab-1/ GM-Tg-cang-MP2166-Ab-2Anti-Canine IQGAP1 monoclonal antibodyCanine
GM-Tg-bovg-MP2166-Ab-1/ GM-Tg-bovg-MP2166-Ab-2Anti-Bovine IQGAP1 monoclonal antibodyBovine
GM-Tg-equg-MP2166-Ab-1/ GM-Tg-equg-MP2166-Ab-2Anti-Equine IQGAP1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2166-Ab-1/ GM-Tg-hg-MP2166-Ab-2; GM-Tg-rg-MP2166-Ab-1/ GM-Tg-rg-MP2166-Ab-2;
GM-Tg-mg-MP2166-Ab-1/ GM-Tg-mg-MP2166-Ab-2; GM-Tg-cynog-MP2166-Ab-1/ GM-Tg-cynog-MP2166-Ab-2;
GM-Tg-felg-MP2166-Ab-1/ GM-Tg-felg-MP2166-Ab-2; GM-Tg-cang-MP2166-Ab-1/ GM-Tg-cang-MP2166-Ab-2;
GM-Tg-bovg-MP2166-Ab-1/ GM-Tg-bovg-MP2166-Ab-2; GM-Tg-equg-MP2166-Ab-1/ GM-Tg-equg-MP2166-Ab-2
Products NameAnti-IQGAP1 monoclonal antibody
Formatmab
Target NameIQGAP1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IQGAP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species IQGA1/ IQGAP1/ HUMORFA01 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2166
    Target NameIQGAP1
    Gene ID8826,29875,361598,709283,479050,101087841,104968536,100068724
    Gene Symbol and SynonymsD7Ertd237e,D7Ertd257e,HUMORFA01,IQGAP1,mKIAA0051,p195,SAR1
    Uniprot AccessionP46940
    Uniprot Entry NameIQGA1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000140575
    Target ClassificationN/A

    The target: IQGAP1, gene name: IQGAP1, also named as HUMORFA01, SAR1, p195. This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.