Anti-IQGA2/ IQGAP2 monoclonal antibody

Anti-IQGA2/ IQGAP2 antibody for FACS & in-vivo assay

Target products collectionGo to IQGAP2/IQGAP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2167-Ab-1/ GM-Tg-hg-MP2167-Ab-2Anti-Human IQGAP2 monoclonal antibodyHuman
GM-Tg-rg-MP2167-Ab-1/ GM-Tg-rg-MP2167-Ab-2Anti-Rat IQGAP2 monoclonal antibodyRat
GM-Tg-mg-MP2167-Ab-1/ GM-Tg-mg-MP2167-Ab-2Anti-Mouse IQGAP2 monoclonal antibodyMouse
GM-Tg-cynog-MP2167-Ab-1/ GM-Tg-cynog-MP2167-Ab-2Anti-Cynomolgus/ Rhesus macaque IQGAP2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2167-Ab-1/ GM-Tg-felg-MP2167-Ab-2Anti-Feline IQGAP2 monoclonal antibodyFeline
GM-Tg-cang-MP2167-Ab-1/ GM-Tg-cang-MP2167-Ab-2Anti-Canine IQGAP2 monoclonal antibodyCanine
GM-Tg-bovg-MP2167-Ab-1/ GM-Tg-bovg-MP2167-Ab-2Anti-Bovine IQGAP2 monoclonal antibodyBovine
GM-Tg-equg-MP2167-Ab-1/ GM-Tg-equg-MP2167-Ab-2Anti-Equine IQGAP2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2167-Ab-1/ GM-Tg-hg-MP2167-Ab-2; GM-Tg-rg-MP2167-Ab-1/ GM-Tg-rg-MP2167-Ab-2;
GM-Tg-mg-MP2167-Ab-1/ GM-Tg-mg-MP2167-Ab-2; GM-Tg-cynog-MP2167-Ab-1/ GM-Tg-cynog-MP2167-Ab-2;
GM-Tg-felg-MP2167-Ab-1/ GM-Tg-felg-MP2167-Ab-2; GM-Tg-cang-MP2167-Ab-1/ GM-Tg-cang-MP2167-Ab-2;
GM-Tg-bovg-MP2167-Ab-1/ GM-Tg-bovg-MP2167-Ab-2; GM-Tg-equg-MP2167-Ab-1/ GM-Tg-equg-MP2167-Ab-2
Products NameAnti-IQGAP2 monoclonal antibody
Formatmab
Target NameIQGAP2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IQGAP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species IQGA2/ IQGAP2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2167
    Target NameIQGAP2
    Gene ID10788,544963,100360623,712026,479177,101082373,782315,100073279
    Gene Symbol and Synonyms4933417J23Rik,A630053O10,IQGAP2
    Uniprot AccessionQ13576
    Uniprot Entry NameIQGA2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000145703
    Target ClassificationN/A

    The target: IQGAP2, gene name: IQGAP2, also named as . This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.