Anti-ITSN2/ PRO2015/ SH3D1B monoclonal antibody

Anti-ITSN2/ PRO2015/ SH3D1B antibody for FACS & in-vivo assay

Target products collectionGo to ITSN2/ITSN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2168-Ab-1/ GM-Tg-hg-MP2168-Ab-2Anti-Human ITSN2 monoclonal antibodyHuman
GM-Tg-rg-MP2168-Ab-1/ GM-Tg-rg-MP2168-Ab-2Anti-Rat ITSN2 monoclonal antibodyRat
GM-Tg-mg-MP2168-Ab-1/ GM-Tg-mg-MP2168-Ab-2Anti-Mouse ITSN2 monoclonal antibodyMouse
GM-Tg-cynog-MP2168-Ab-1/ GM-Tg-cynog-MP2168-Ab-2Anti-Cynomolgus/ Rhesus macaque ITSN2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2168-Ab-1/ GM-Tg-felg-MP2168-Ab-2Anti-Feline ITSN2 monoclonal antibodyFeline
GM-Tg-cang-MP2168-Ab-1/ GM-Tg-cang-MP2168-Ab-2Anti-Canine ITSN2 monoclonal antibodyCanine
GM-Tg-bovg-MP2168-Ab-1/ GM-Tg-bovg-MP2168-Ab-2Anti-Bovine ITSN2 monoclonal antibodyBovine
GM-Tg-equg-MP2168-Ab-1/ GM-Tg-equg-MP2168-Ab-2Anti-Equine ITSN2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2168-Ab-1/ GM-Tg-hg-MP2168-Ab-2; GM-Tg-rg-MP2168-Ab-1/ GM-Tg-rg-MP2168-Ab-2;
GM-Tg-mg-MP2168-Ab-1/ GM-Tg-mg-MP2168-Ab-2; GM-Tg-cynog-MP2168-Ab-1/ GM-Tg-cynog-MP2168-Ab-2;
GM-Tg-felg-MP2168-Ab-1/ GM-Tg-felg-MP2168-Ab-2; GM-Tg-cang-MP2168-Ab-1/ GM-Tg-cang-MP2168-Ab-2;
GM-Tg-bovg-MP2168-Ab-1/ GM-Tg-bovg-MP2168-Ab-2; GM-Tg-equg-MP2168-Ab-1/ GM-Tg-equg-MP2168-Ab-2
Products NameAnti-ITSN2 monoclonal antibody
Formatmab
Target NameITSN2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITSN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ITSN2/ PRO2015/ SH3D1B VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2168
    Target NameITSN2
    Gene ID50618,20403,313934,704858,475683,101095168,521706,100056119
    Gene Symbol and SynonymsEse2,ITSN2,mKIAA1256,PRO2015,SH3D1B,SH3P18,SWA,SWAP
    Uniprot AccessionQ9NZM3
    Uniprot Entry NameITSN2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000198399
    Target ClassificationN/A

    The target: ITSN2, gene name: ITSN2, also named as PRO2015, SH3D1B, SH3P18, SWA, SWAP. This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.