Anti-KANK1/ ANKRD15/ CPSQ2 monoclonal antibody

Anti-KANK1/ ANKRD15/ CPSQ2 antibody for FACS & in-vivo assay

Target products collectionGo to KANK1/KANK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2170-Ab-1/ GM-Tg-hg-MP2170-Ab-2Anti-Human KANK1 monoclonal antibodyHuman
GM-Tg-rg-MP2170-Ab-1/ GM-Tg-rg-MP2170-Ab-2Anti-Rat KANK1 monoclonal antibodyRat
GM-Tg-mg-MP2170-Ab-1/ GM-Tg-mg-MP2170-Ab-2Anti-Mouse KANK1 monoclonal antibodyMouse
GM-Tg-cynog-MP2170-Ab-1/ GM-Tg-cynog-MP2170-Ab-2Anti-Cynomolgus/ Rhesus macaque KANK1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2170-Ab-1/ GM-Tg-felg-MP2170-Ab-2Anti-Feline KANK1 monoclonal antibodyFeline
GM-Tg-cang-MP2170-Ab-1/ GM-Tg-cang-MP2170-Ab-2Anti-Canine KANK1 monoclonal antibodyCanine
GM-Tg-bovg-MP2170-Ab-1/ GM-Tg-bovg-MP2170-Ab-2Anti-Bovine KANK1 monoclonal antibodyBovine
GM-Tg-equg-MP2170-Ab-1/ GM-Tg-equg-MP2170-Ab-2Anti-Equine KANK1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2170-Ab-1/ GM-Tg-hg-MP2170-Ab-2; GM-Tg-rg-MP2170-Ab-1/ GM-Tg-rg-MP2170-Ab-2;
GM-Tg-mg-MP2170-Ab-1/ GM-Tg-mg-MP2170-Ab-2; GM-Tg-cynog-MP2170-Ab-1/ GM-Tg-cynog-MP2170-Ab-2;
GM-Tg-felg-MP2170-Ab-1/ GM-Tg-felg-MP2170-Ab-2; GM-Tg-cang-MP2170-Ab-1/ GM-Tg-cang-MP2170-Ab-2;
GM-Tg-bovg-MP2170-Ab-1/ GM-Tg-bovg-MP2170-Ab-2; GM-Tg-equg-MP2170-Ab-1/ GM-Tg-equg-MP2170-Ab-2
Products NameAnti-KANK1 monoclonal antibody
Formatmab
Target NameKANK1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KANK1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KANK1/ ANKRD15/ CPSQ2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2170
    Target NameKANK1
    Gene ID23189,107351,309429,697569,100687276,101101346,534869,100050757
    Gene Symbol and SynonymsA930031B09Rik,ANKRD15,CPSQ2,D330024H06Rik,KANK,KANK1,mKIAA0172
    Uniprot AccessionQ14678
    Uniprot Entry NameKANK1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000107104
    Target ClassificationN/A

    The target: KANK1, gene name: KANK1, also named as ANKRD15, CPSQ2, KANK. The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.