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Anti-SKAP/ KNSTRN/ C15orf23 monoclonal antibody
Anti-SKAP/ KNSTRN/ C15orf23 antibody for FACS & in-vivo assay
Go to KNSTRN/KNSTRN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2179-Ab-1/ GM-Tg-hg-MP2179-Ab-2 | Anti-Human KNSTRN monoclonal antibody | Human |
| GM-Tg-rg-MP2179-Ab-1/ GM-Tg-rg-MP2179-Ab-2 | Anti-Rat KNSTRN monoclonal antibody | Rat |
| GM-Tg-mg-MP2179-Ab-1/ GM-Tg-mg-MP2179-Ab-2 | Anti-Mouse KNSTRN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2179-Ab-1/ GM-Tg-cynog-MP2179-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KNSTRN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2179-Ab-1/ GM-Tg-felg-MP2179-Ab-2 | Anti-Feline KNSTRN monoclonal antibody | Feline |
| GM-Tg-cang-MP2179-Ab-1/ GM-Tg-cang-MP2179-Ab-2 | Anti-Canine KNSTRN monoclonal antibody | Canine |
| GM-Tg-bovg-MP2179-Ab-1/ GM-Tg-bovg-MP2179-Ab-2 | Anti-Bovine KNSTRN monoclonal antibody | Bovine |
| GM-Tg-equg-MP2179-Ab-1/ GM-Tg-equg-MP2179-Ab-2 | Anti-Equine KNSTRN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2179-Ab-1/ GM-Tg-hg-MP2179-Ab-2; GM-Tg-rg-MP2179-Ab-1/ GM-Tg-rg-MP2179-Ab-2; GM-Tg-mg-MP2179-Ab-1/ GM-Tg-mg-MP2179-Ab-2; GM-Tg-cynog-MP2179-Ab-1/ GM-Tg-cynog-MP2179-Ab-2; GM-Tg-felg-MP2179-Ab-1/ GM-Tg-felg-MP2179-Ab-2; GM-Tg-cang-MP2179-Ab-1/ GM-Tg-cang-MP2179-Ab-2; GM-Tg-bovg-MP2179-Ab-1/ GM-Tg-bovg-MP2179-Ab-2; GM-Tg-equg-MP2179-Ab-1/ GM-Tg-equg-MP2179-Ab-2 |
| Products Name | Anti-KNSTRN monoclonal antibody |
| Format | mab |
| Target Name | KNSTRN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KNSTRN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SKAP/ KNSTRN/ C15orf23 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP005054 | human KNSTRN Lentivirus particle |
| ORF Viral Vector | pGMLP005054 | human KNSTRN Lentivirus plasmid |
Target information
| Target ID | GM-MP2179 |
| Target Name | KNSTRN |
| Gene ID | 90417,51944,311325,702753,100856281,101087160,507864,100071423 |
| Gene Symbol and Synonyms | 1700025D04Rik,C10H15orf23,C15orf23,C7H15orf23,CB3H15orf23,D2Ertd750e,HSD11,KNSTRN,ROCHIS,SKAP,TRAF4AF1 |
| Uniprot Accession | Q9Y448,Q6AXN6 |
| Uniprot Entry Name | SKAP_HUMAN,SKAP_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000128944 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: KNSTRN, gene name: KNSTRN, also named as C15orf23, HSD11, SKAP, TRAF4AF1. Enables microtubule plus-end binding activity and protein homodimerization activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and ruffle. Implicated in actinic keratosis and skin squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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