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Anti-LDB2/ CLIM1/ LDB-2 monoclonal antibody
Anti-LDB2/ CLIM1/ LDB-2 antibody for FACS & in-vivo assay
Go to LDB2/LDB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2183-Ab-1/ GM-Tg-hg-MP2183-Ab-2 | Anti-Human LDB2 monoclonal antibody | Human |
| GM-Tg-rg-MP2183-Ab-1/ GM-Tg-rg-MP2183-Ab-2 | Anti-Rat LDB2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2183-Ab-1/ GM-Tg-mg-MP2183-Ab-2 | Anti-Mouse LDB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2183-Ab-1/ GM-Tg-cynog-MP2183-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LDB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2183-Ab-1/ GM-Tg-felg-MP2183-Ab-2 | Anti-Feline LDB2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2183-Ab-1/ GM-Tg-cang-MP2183-Ab-2 | Anti-Canine LDB2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2183-Ab-1/ GM-Tg-bovg-MP2183-Ab-2 | Anti-Bovine LDB2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2183-Ab-1/ GM-Tg-equg-MP2183-Ab-2 | Anti-Equine LDB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2183-Ab-1/ GM-Tg-hg-MP2183-Ab-2; GM-Tg-rg-MP2183-Ab-1/ GM-Tg-rg-MP2183-Ab-2; GM-Tg-mg-MP2183-Ab-1/ GM-Tg-mg-MP2183-Ab-2; GM-Tg-cynog-MP2183-Ab-1/ GM-Tg-cynog-MP2183-Ab-2; GM-Tg-felg-MP2183-Ab-1/ GM-Tg-felg-MP2183-Ab-2; GM-Tg-cang-MP2183-Ab-1/ GM-Tg-cang-MP2183-Ab-2; GM-Tg-bovg-MP2183-Ab-1/ GM-Tg-bovg-MP2183-Ab-2; GM-Tg-equg-MP2183-Ab-1/ GM-Tg-equg-MP2183-Ab-2 |
| Products Name | Anti-LDB2 monoclonal antibody |
| Format | mab |
| Target Name | LDB2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LDB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LDB2/ CLIM1/ LDB-2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002860 | human LDB2 Lentivirus particle |
| ORF Viral Vector | pGMLP002860 | human LDB2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005193 | mouse Ldb2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005193 | mouse Ldb2 Lentivirus particle |
Target information
| Target ID | GM-MP2183 |
| Target Name | LDB2 |
| Gene ID | 9079,16826,289664,714918,479084,101094670,617976,100055850 |
| Gene Symbol and Synonyms | CLIM1,CLP-36,LDB-2,LDB1,LDB2,Ldb3 |
| Uniprot Accession | O43679 |
| Uniprot Entry Name | LDB2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000169744 |
| Target Classification | N/A |
The target: LDB2, gene name: LDB2, also named as CLIM1, LDB-2, LDB1. The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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