Anti-LRRC7/ DENSIN monoclonal antibody

Anti-LRRC7/ DENSIN antibody for FACS & in-vivo assay

Target products collectionGo to LRRC7/LRRC7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2188-Ab-1/ GM-Tg-hg-MP2188-Ab-2Anti-Human LRRC7 monoclonal antibodyHuman
GM-Tg-rg-MP2188-Ab-1/ GM-Tg-rg-MP2188-Ab-2Anti-Rat LRRC7 monoclonal antibodyRat
GM-Tg-mg-MP2188-Ab-1/ GM-Tg-mg-MP2188-Ab-2Anti-Mouse LRRC7 monoclonal antibodyMouse
GM-Tg-cynog-MP2188-Ab-1/ GM-Tg-cynog-MP2188-Ab-2Anti-Cynomolgus/ Rhesus macaque LRRC7 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2188-Ab-1/ GM-Tg-felg-MP2188-Ab-2Anti-Feline LRRC7 monoclonal antibodyFeline
GM-Tg-cang-MP2188-Ab-1/ GM-Tg-cang-MP2188-Ab-2Anti-Canine LRRC7 monoclonal antibodyCanine
GM-Tg-bovg-MP2188-Ab-1/ GM-Tg-bovg-MP2188-Ab-2Anti-Bovine LRRC7 monoclonal antibodyBovine
GM-Tg-equg-MP2188-Ab-1/ GM-Tg-equg-MP2188-Ab-2Anti-Equine LRRC7 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2188-Ab-1/ GM-Tg-hg-MP2188-Ab-2; GM-Tg-rg-MP2188-Ab-1/ GM-Tg-rg-MP2188-Ab-2;
GM-Tg-mg-MP2188-Ab-1/ GM-Tg-mg-MP2188-Ab-2; GM-Tg-cynog-MP2188-Ab-1/ GM-Tg-cynog-MP2188-Ab-2;
GM-Tg-felg-MP2188-Ab-1/ GM-Tg-felg-MP2188-Ab-2; GM-Tg-cang-MP2188-Ab-1/ GM-Tg-cang-MP2188-Ab-2;
GM-Tg-bovg-MP2188-Ab-1/ GM-Tg-bovg-MP2188-Ab-2; GM-Tg-equg-MP2188-Ab-1/ GM-Tg-equg-MP2188-Ab-2
Products NameAnti-LRRC7 monoclonal antibody
Formatmab
Target NameLRRC7
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRRC7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRRC7/ DENSIN VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP2188
    Target NameLRRC7
    Gene ID57554,242274,117284,702347,490218,101083021,538844,100068467
    Gene Symbol and SynonymsDENSIN,LRRC7,mKIAA1365
    Uniprot AccessionQ96NW7,P70587,F1MCA7
    Uniprot Entry NameLRRC7_HUMAN,LRRC7_RAT,LRRC7_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000033122
    Target ClassificationN/A

    The target: LRRC7, gene name: LRRC7, also named as DENSIN. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of neuron projection development; and receptor clustering. Located in several cellular components, including centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.